The murine cytomegalovirus M73.5 gene, a member of a 3' co-terminal alternatively spliced gene family, encodes the gp24 virion glycoprotein

Tony Scalzo, Peter Dallas, Catherine Forbes, A.S.J. Mikosza, Peter Fleming, Louise Lathbury, P.A. Lyons, S. Laferte, M.M. Craggs, L.C. Loh

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

We have identified a novel family of five 3' co-terminal transcripts in murine cytomegalovirus (MCMV) arranged in a tail-to-tail orientation with respect to the MCMV glycoprotein H (gH) gene M75. They share the same exon 2 sequence but possess different exon I sequences. Two of these spliced transcripts (M73) encode the MCMV homolog of glycoprotein N (gN) entirely within exon 1. Two other transcripts designated M73.5 encode a previously described virion glycoprotein gp24 that shares its first 20 amino acids with gN, but which has another 64 amino acids encoded within exon 2. The fifth transcript, designated m60, has an 80-bp exon 1 near the MCMV oriLyt region 10.8 kb upstream of exon 2. Both MCMV M73.5 and m60 encode type 11 glycoproteins expressed at the cell surface. Their shared exon 2 coding sequences likely represent the highly conserved region of an as yet unidentified betaherpesvirus-specific glycoprotein species. (C) 2004 Elsevier Inc. All rights reserved.
Original languageEnglish
Pages (from-to)234-250
JournalVirology
Volume329
Issue number2
DOIs
Publication statusPublished - 2004

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