TY - JOUR
T1 - The Multiple Roles of Urocanic Acid in Health and Disease
AU - Hart, Prue H.
AU - Norval, Mary
PY - 2021/3
Y1 - 2021/3
N2 - Trans-urocanic acid (trans-UCA) is synthesized in the skin, liver, and brain. It is a major natural moisturizing factor in skin and maintains its acid pH. In skin, it isomerizes to cis-UCA following exposure to UVR. Both isomers fulfill multiple roles in health and disease. Cis-UCA has immunomodulatory properties linked with several cutaneous diseases such as skin cancer, atopic dermatitis, and urticaria and associates with systemic diseases including multiple sclerosis. The levels of UCA in the skin, brain, urine, and feces reflect some physiological processes and may be disease biomarkers. Both isomers of UCA have therapeutic potential for a range of disorders.
AB - Trans-urocanic acid (trans-UCA) is synthesized in the skin, liver, and brain. It is a major natural moisturizing factor in skin and maintains its acid pH. In skin, it isomerizes to cis-UCA following exposure to UVR. Both isomers fulfill multiple roles in health and disease. Cis-UCA has immunomodulatory properties linked with several cutaneous diseases such as skin cancer, atopic dermatitis, and urticaria and associates with systemic diseases including multiple sclerosis. The levels of UCA in the skin, brain, urine, and feces reflect some physiological processes and may be disease biomarkers. Both isomers of UCA have therapeutic potential for a range of disorders.
UR - http://www.scopus.com/inward/record.url?scp=85090489212&partnerID=8YFLogxK
U2 - 10.1016/j.jid.2020.07.017
DO - 10.1016/j.jid.2020.07.017
M3 - Review article
C2 - 32919759
AN - SCOPUS:85090489212
VL - 141
SP - 496
EP - 502
JO - The Journal of Investigative Dermatology
JF - The Journal of Investigative Dermatology
SN - 0022-202X
IS - 3
ER -
