The mouse as a model for the effects of MHC genes on human disease

Richard Allcock; A.M. Martin; Patricia Price

doi:10.1016/S0167-5699(00)01654-6

The mouse as a model for the effects of MHC genes on human disease

Richard Allcock, A.M. Martin, Patricia Price

Research output: Contribution to journal › Article › peer-review

34 Citations (Web of Science)

Abstract

As mice are often used to model human major histocompatibility complex (MHC)-associated diseases, if is important to understand how their MHC regions differ at the DNA level. The sequencing of the mouse MHC (H2 region) has enabled a detailed map of this region to be assembled for comparison with the human MHC. Here, Richard Allcock and colleagues outline the similarities between the human and mouse MHC regions and discuss notable differences that might affect disease models.

Original language	English
Pages (from-to)	328-332
Journal	Immunology Today
Volume	21
Issue number	7
DOIs	https://doi.org/10.1016/S0167-5699(00)01654-6
Publication status	Published - 2000

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10.1016/S0167-5699(00)01654-6

Cite this

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KW - Humans

KW - Major Histocompatibility Complex/genetics

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KW - Species Specificity

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The mouse as a model for the effects of MHC genes on human disease

Abstract

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