The modulation of ischaemia reperfusion injury

Alizan Abdul Khalil

    Research output: ThesisDoctoral Thesis

    15 Downloads (Pure)


    [Truncated] Reperfusion injury occurs in ischaemic tissues after the restoration of blood supply. It adds to the damage due to ischaemia and it can involve remote organs.Some clinical emergencies involve ischaemia reperfusion injury. These include traumatic amputations of limbs and thromboembolic events such as strokes, myocardial infarcts, and vascular accidents. In these scenarios, there is no opportunity for any prophylactic pre-ischaemic therapy. The management of patients in this situation involves the restoration of blood supply and supportive treatment to reduce the extent of ischaemia reperfusion injury in local and remote organs.The pathobiology of ischaemia reperfusion injury involves most defensive effects or mechanisms generated by leukocytes and macrophages. Included here are the reactive oxygen species, complement, nitric oxide, and cytokines including TNFα. There is a need to identify the reversible stem events and develop prophylactic interventions for situations that can lead to ischaemia reperfusion injury, such organ transplantation and cardio-vascular surgery.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    Publication statusUnpublished - 2006

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