The mechanism of selenium-induced skeletal muscle dysfunction and weakness

Thomas Wilson

doi:10.4225/23/5b2af9b60e3f8

The mechanism of selenium-induced skeletal muscle dysfunction and weakness

Thomas Wilson

School of Human Sciences

Research output: Thesis › Master's Thesis

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Abstract

Selenium toxicity induces pathological skeletal muscle contracture in many animal-models, and can result in respiratory failure. Previous research suggests the main cause of selenium-induced contracture is the oxidation of ryanodine receptors, causing uncontrolled Ca2+release. The results of this thesis show that selenium-induced contracture can occur by multiple independent mechanisms. These mechanisms involve changes to cellular redox state, which impair the function of the SE RCA pump and reduce the sensitivity of the contractile apparatus to Ca2+. This thesis also presents the possibility that selenium-induced contracture could be caused by mitochondrial-mediated cell death resulting in a rigor contracture.

Original language	English
Qualification	Masters
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Bakker, Tony, Supervisor Pinniger, Gavin, Supervisor White, Robert, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	1 Jun 2018
DOIs	https://doi.org/10.4225/23/5b2af9b60e3f8
Publication status	Unpublished - 2018

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THESIS - MASTER OF PHILOSOPHY - WILSON Thomas Patrick - 2018
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title = "The mechanism of selenium-induced skeletal muscle dysfunction and weakness",

abstract = "Selenium toxicity induces pathological skeletal muscle contracture in many animal-models, and can result in respiratory failure. Previous research suggests the main cause of selenium-induced contracture is the oxidation of ryanodine receptors, causing uncontrolled Ca2+release. The results of this thesis show that selenium-induced contracture can occur by multiple independent mechanisms. These mechanisms involve changes to cellular redox state, which impair the function of the SE RCA pump and reduce the sensitivity of the contractile apparatus to Ca2+. This thesis also presents the possibility that selenium-induced contracture could be caused by mitochondrial-mediated cell death resulting in a rigor contracture.",

keywords = "selenium, skeletal, toxicity, selenite, muscle, sodium selenite",

author = "Thomas Wilson",

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doi = "10.4225/23/5b2af9b60e3f8",

language = "English",

school = "The University of Western Australia",

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T1 - The mechanism of selenium-induced skeletal muscle dysfunction and weakness

AU - Wilson, Thomas

PY - 2018

Y1 - 2018

N2 - Selenium toxicity induces pathological skeletal muscle contracture in many animal-models, and can result in respiratory failure. Previous research suggests the main cause of selenium-induced contracture is the oxidation of ryanodine receptors, causing uncontrolled Ca2+release. The results of this thesis show that selenium-induced contracture can occur by multiple independent mechanisms. These mechanisms involve changes to cellular redox state, which impair the function of the SE RCA pump and reduce the sensitivity of the contractile apparatus to Ca2+. This thesis also presents the possibility that selenium-induced contracture could be caused by mitochondrial-mediated cell death resulting in a rigor contracture.

AB - Selenium toxicity induces pathological skeletal muscle contracture in many animal-models, and can result in respiratory failure. Previous research suggests the main cause of selenium-induced contracture is the oxidation of ryanodine receptors, causing uncontrolled Ca2+release. The results of this thesis show that selenium-induced contracture can occur by multiple independent mechanisms. These mechanisms involve changes to cellular redox state, which impair the function of the SE RCA pump and reduce the sensitivity of the contractile apparatus to Ca2+. This thesis also presents the possibility that selenium-induced contracture could be caused by mitochondrial-mediated cell death resulting in a rigor contracture.

KW - selenium

KW - skeletal

KW - toxicity

KW - selenite

KW - muscle

KW - sodium selenite

U2 - 10.4225/23/5b2af9b60e3f8

DO - 10.4225/23/5b2af9b60e3f8

M3 - Master's Thesis

ER -

The mechanism of selenium-induced skeletal muscle dysfunction and weakness

Abstract

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