The Longitudinal Investigation of Gastrointestinal Symptoms and The Gut Microbiome in Australians with Parkinson’s Disease

Jade Kenna

doi:10.26182/te06-bm48

The Longitudinal Investigation of Gastrointestinal Symptoms and The Gut Microbiome in Australians with Parkinson’s Disease

Jade Kenna

Research output: Thesis › Doctoral Thesis

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Abstract

Parkinson’s disease is a neurological disorder that has recently been linked to the gut, and is rapidly growing in prevalence. This thesis investigated the impact of the gut in Parkinson’s disease through a novel multi-site Australian study. In our cohort, gastrointestinal symptoms were significantly more severe in patients, and had a negative influence on quality of life. Biologically, the gut microbiome showed a reduced diversity and altered composition, with corresponding changes in microbial metabolites, which associated with a declining phenotype. Clinically, this thesis provides the foundation for improved patient care and the potential for a prognostic marker of disease trajectory.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Tay, Alfred, Supervisor Anderton, Ryan, Supervisor Palmer, Norman, Supervisor Mastaglia, Frank, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	23 Jun 2023
DOIs	https://doi.org/10.26182/te06-bm48
Publication status	Unpublished - 2023

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10.26182/te06-bm48

THESIS - DOCTOR OF PHILOSOPHY - KENNA Jade - 2023
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2 Article

Impact of Gastrointestinal Symptoms on Health-Related Quality of Life in an Australian Parkinson's Disease Cohort
Kenna, J. E. E., Bakeberg, M. C. C., Abonnel, M. Y. Y., Mastaglia, F. L. L. & Anderton, R. S. S., 25 Nov 2022, In: Parkinson's Disease. 2022, 8 p., 4053665.
Research output: Contribution to journal › Article › peer-review

Open Access
4 Citations (Scopus)
Changes in the Gut Microbiome and Predicted Functional Metabolic Effects in an Australian Parkinson's Disease Cohort
Kenna, J. E., Chua, E. G., Bakeberg, M., Tay, A., McGregor, S., Gorecki, A., Horne, M., Marshall, B., Mastaglia, F. L. & Anderton, R. S., 29 Oct 2021, In: Frontiers in Neuroscience. 15, p. 756951 756951.
Research output: Contribution to journal › Article › peer-review

Open Access
20 Citations (Scopus)

Cite this

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AB - Parkinson’s disease is a neurological disorder that has recently been linked to the gut, and is rapidly growing in prevalence. This thesis investigated the impact of the gut in Parkinson’s disease through a novel multi-site Australian study. In our cohort, gastrointestinal symptoms were significantly more severe in patients, and had a negative influence on quality of life. Biologically, the gut microbiome showed a reduced diversity and altered composition, with corresponding changes in microbial metabolites, which associated with a declining phenotype. Clinically, this thesis provides the foundation for improved patient care and the potential for a prognostic marker of disease trajectory.

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KW - gut microbiome

KW - SCFAs

KW - gastrointestinal symptoms

KW - quality of life

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M3 - Doctoral Thesis

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The Longitudinal Investigation of Gastrointestinal Symptoms and The Gut Microbiome in Australians with Parkinson’s Disease

Abstract

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Research output

Impact of Gastrointestinal Symptoms on Health-Related Quality of Life in an Australian Parkinson's Disease Cohort

Changes in the Gut Microbiome and Predicted Functional Metabolic Effects in an Australian Parkinson's Disease Cohort

Cite this