The Longitudinal Investigation of Gastrointestinal Symptoms and The Gut Microbiome in Australians with Parkinson’s Disease

Jade Kenna

Research output: ThesisDoctoral Thesis

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Abstract

Parkinson’s disease is a neurological disorder that has recently been linked to the gut, and is rapidly growing in prevalence. This thesis investigated the impact of the gut in Parkinson’s disease through a novel multi-site Australian study. In our cohort, gastrointestinal symptoms were significantly more severe in patients, and had a negative influence on quality of life. Biologically, the gut microbiome showed a reduced diversity and altered composition, with corresponding changes in microbial metabolites, which associated with a declining phenotype. Clinically, this thesis provides the foundation for improved patient care and the potential for a prognostic marker of disease trajectory.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Tay, Alfred, Supervisor
  • Anderton, Ryan, Supervisor
  • Palmer, Norman, Supervisor
  • Mastaglia, Frank, Supervisor
Thesis sponsors
Award date23 Jun 2023
DOIs
Publication statusUnpublished - 2023

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