The long non-coding RNA NEAT1 seeded paraspeckles are mechanosensitive in cancer cells

Research output: ThesisDoctoral Thesis

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Abstract

Changes in tissue stiffness, driven by dysregulated extracellular matrix remodelling, are prevalent throughout cancer. Metastatic cancer cells further experience mechanical challenges from confinement and mechanical cues from both stiffness and confinement can regulate cellular responses through mechanotransduction. Yet our understanding of how the nuclear interior responds remains limited. Here I investigate whether cancer-associated subnuclear bodies, paraspeckles, are mechanosensitive in cancer. I report an inverse relationship between paraspeckles and stiffness, describe a relationship between a well-studied mechanosensitive protein, and show that paraspeckles are regulated during confinement.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Fox, Archa, Supervisor
  • Choi, Yu Suk, Supervisor
Thesis sponsors
Award date18 Jul 2021
DOIs
Publication statusUnpublished - 2021

Embargo information

  • Embargoed from 02/08/2021 to 29/07/2022. Made publicly available on 29/07/2022.

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