Abstract
Changes in tissue stiffness, driven by dysregulated extracellular matrix remodelling, are prevalent throughout cancer. Metastatic cancer cells further experience mechanical challenges from confinement and mechanical cues from both stiffness and confinement can regulate cellular responses through mechanotransduction. Yet our understanding of how the nuclear interior responds remains limited. Here I investigate whether cancer-associated subnuclear bodies, paraspeckles, are mechanosensitive in cancer. I report an inverse relationship between paraspeckles and stiffness, describe a relationship between a well-studied mechanosensitive protein, and show that paraspeckles are regulated during confinement.
| Original language | English |
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| Qualification | Doctor of Philosophy |
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| Award date | 18 Jul 2021 |
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| Publication status | Unpublished - 2021 |
Embargo information
- Embargoed from 02/08/2021 to 29/07/2022. Made publicly available on 29/07/2022.
Access to Document
- THESIS - DOCTOR OF PHILOSOPHY - TODOROVSKI, Vanja - 2021
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