TY - JOUR
T1 - The L-type Ca2+ Channel as a Potential Mediator of Pathology During Alterations in Cellular Redox State
AU - Hool, Livia
PY - 2009
Y1 - 2009
N2 - The L-type Ca2+ channel is the main route for calcium influx into cardiac myocytes and an important determinant of calcium homeostasis. There is now considerable evidence that the function of the L-type Ca2+ channel is influenced by the cell's redox state. Reactive oxygen species such as hydrogen peroxide and superoxide can regulate biological function by directly altering the thiol redox state of proteins. Under conditions where cellular redox state varies, L-type Ca2+ channel function and diastolic calcium levels can be significantly altered. This article will present the evidence for alterations in L-type Ca2+ channel function by reactive oxygen species and the potential role for the channel in development of acute electrophysiological instability or chronic pathological remodelling under conditions of persistent oxidative stress.
AB - The L-type Ca2+ channel is the main route for calcium influx into cardiac myocytes and an important determinant of calcium homeostasis. There is now considerable evidence that the function of the L-type Ca2+ channel is influenced by the cell's redox state. Reactive oxygen species such as hydrogen peroxide and superoxide can regulate biological function by directly altering the thiol redox state of proteins. Under conditions where cellular redox state varies, L-type Ca2+ channel function and diastolic calcium levels can be significantly altered. This article will present the evidence for alterations in L-type Ca2+ channel function by reactive oxygen species and the potential role for the channel in development of acute electrophysiological instability or chronic pathological remodelling under conditions of persistent oxidative stress.
U2 - 10.1016/j.hlc.2008.11.004
DO - 10.1016/j.hlc.2008.11.004
M3 - Article
C2 - 19119068
SN - 1443-9506
VL - 18
SP - 1
EP - 8
JO - Heart, Lung & Circulation
JF - Heart, Lung & Circulation
IS - 1
ER -