Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 134-139 |
| Journal | Australian and New Zealand Journal of Obstetrics and Gynecology |
| Volume | 59 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Feb 2019 |
Fingerprint
Cite this
}
The interval transfer of a frozen‐thawed embryo is more successful than a fresh embryo transfer for women undergoing IVF with recurrent implantation failure after cleavage stage embryo biopsy. / Pontre, Jennifer; Ryan, John P.; Tan, Andy; Hart, Roger.
In: Australian and New Zealand Journal of Obstetrics and Gynecology, Vol. 59, No. 1, 02.2019, p. 134-139.Research output: Contribution to journal › Article
TY - JOUR
T1 - The interval transfer of a frozen‐thawed embryo is more successful than a fresh embryo transfer for women undergoing IVF with recurrent implantation failure after cleavage stage embryo biopsy
AU - Pontre, Jennifer
AU - Ryan, John P.
AU - Tan, Andy
AU - Hart, Roger
PY - 2019/2
Y1 - 2019/2
N2 - Background: Recurrent implantation failure (RIF) is repeated unsuccessful embryo transfers (ETs). Aims: To identify predictive embryonic markers of implantation in RIF, following pre-implantation genetic screening (PGS) of cleavage stage embryos, after accounting for male and female factors. Materials and Methods: Retrospective analysis of RIF patients undergoing PGS after correction of modifiable causes. Results: Eighty-four patients underwent 140 in vitro ferilisation cycles. Forty-one cycles were excluded: 12 (no embryo for transfer), four (double ETs) and 25 (no biopsy). Sixty-three patients underwent 99 single euploid ETs (48 fresh, 51 frozen) resulting in 11 biochemical pregnancies, 36 clinical pregnancies (CP), and six miscarriages and 30 live births (LB). Frozen ET was more successful than fresh; respective live birth rate (LBR) and clinical pregnancy rate (CPR), 39.2% versus 20.8%, (P = 0.02), 45.1% versus 27.1% (P = 0.04). LBR and CPR were lower when 5–6 blastomeres were present at embryo biopsy, compared to embryos with ≥7 blastomeres: 15.4% versus 32.6% (P = 0.185) and 15.4% versus 39.5% (P = 0.074) respectively. Serum β human chorionic gonadotropin (βhCG) concentration was greater when a more developed embryo was biopsied (r = 0.448, P = 0.017 and r = 0.476, P = 0.118, fresh and frozen transfers, respectively). Embryo morphokinetic analysis demonstrated faster development to blastocyst stage when more cells were present at biopsy: mean 103.3, 102.2 and 96.0 h for biopsy at the 5–6, 7–8 or ≥9 cell stage respectively (P = 0.040 for difference between 7–8 cells vs ≥9). Conclusions: After cleavage stage biopsy, frozen ET was more successful than fresh ET. Chance of conception and serum βhCG concentration correlated with number of cells present at time of biopsy. © 2018 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists
AB - Background: Recurrent implantation failure (RIF) is repeated unsuccessful embryo transfers (ETs). Aims: To identify predictive embryonic markers of implantation in RIF, following pre-implantation genetic screening (PGS) of cleavage stage embryos, after accounting for male and female factors. Materials and Methods: Retrospective analysis of RIF patients undergoing PGS after correction of modifiable causes. Results: Eighty-four patients underwent 140 in vitro ferilisation cycles. Forty-one cycles were excluded: 12 (no embryo for transfer), four (double ETs) and 25 (no biopsy). Sixty-three patients underwent 99 single euploid ETs (48 fresh, 51 frozen) resulting in 11 biochemical pregnancies, 36 clinical pregnancies (CP), and six miscarriages and 30 live births (LB). Frozen ET was more successful than fresh; respective live birth rate (LBR) and clinical pregnancy rate (CPR), 39.2% versus 20.8%, (P = 0.02), 45.1% versus 27.1% (P = 0.04). LBR and CPR were lower when 5–6 blastomeres were present at embryo biopsy, compared to embryos with ≥7 blastomeres: 15.4% versus 32.6% (P = 0.185) and 15.4% versus 39.5% (P = 0.074) respectively. Serum β human chorionic gonadotropin (βhCG) concentration was greater when a more developed embryo was biopsied (r = 0.448, P = 0.017 and r = 0.476, P = 0.118, fresh and frozen transfers, respectively). Embryo morphokinetic analysis demonstrated faster development to blastocyst stage when more cells were present at biopsy: mean 103.3, 102.2 and 96.0 h for biopsy at the 5–6, 7–8 or ≥9 cell stage respectively (P = 0.040 for difference between 7–8 cells vs ≥9). Conclusions: After cleavage stage biopsy, frozen ET was more successful than fresh ET. Chance of conception and serum βhCG concentration correlated with number of cells present at time of biopsy. © 2018 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists
U2 - 10.1111/ajo.12798
DO - 10.1111/ajo.12798
M3 - Article
VL - 59
SP - 134
EP - 139
JO - The Australian and New Zealand Journal of Obstetrics and Gynaecology
JF - The Australian and New Zealand Journal of Obstetrics and Gynaecology
SN - 0004-8666
IS - 1
ER -