TY - JOUR
T1 - The influence of physical activity on vascular complications and mortality in patients with type 2 diabetes mellitus
AU - Blomster, J. I.
AU - Chow, C. K.
AU - Zoungas, S.
AU - Woodward, M.
AU - Patel, A.
AU - Poulter, N. R.
AU - Marre, M.
AU - Harrap, S.
AU - Chalmers, J.
AU - Hillis, G. S.
PY - 2013/11/1
Y1 - 2013/11/1
N2 - Aims: There is limited evidence regarding the association between physical activity and vascular complications, particularly microvascular disease, in patients with type 2 diabetes. Methods: From the 11140 patients in the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron modified release Controlled Evaluation) trial, the effect of physical activity, categorized as none, mild, moderate or vigorous, and the number of sessions within a week, was examined in multivariable regression models adjusted for potential confounders. The study end-points were major cardiovascular events, microvascular complications and all-cause mortality. Results: Forty-six percent of participants reported undertaking moderate to vigorous physical activity for >15min at least once in the previous week. During a median of 5years of follow-up, 1031 patients died, 1147 experienced a major cardiovascular event and 1136 a microvascular event. Compared to patients who undertook no or mild physical activity, those reporting moderate to vigorous activity had a decreased risk of cardiovascular events (HR: 0.78, 95% CI: 0.69-0.88, p<0.0001), microvascular events (HR: 0.85, 95% CI: 0.76-0.96, p=0.010) and all-cause mortality (HR: 0.83, 95% CI: 0.73-0.94, p=0.0044). Conclusions: Moderate to vigorous, but not mild, physical activity is associated with a reduced incidence of cardiovascular events, microvascular complications and all-cause mortality in patients with type 2 diabetes.
AB - Aims: There is limited evidence regarding the association between physical activity and vascular complications, particularly microvascular disease, in patients with type 2 diabetes. Methods: From the 11140 patients in the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron modified release Controlled Evaluation) trial, the effect of physical activity, categorized as none, mild, moderate or vigorous, and the number of sessions within a week, was examined in multivariable regression models adjusted for potential confounders. The study end-points were major cardiovascular events, microvascular complications and all-cause mortality. Results: Forty-six percent of participants reported undertaking moderate to vigorous physical activity for >15min at least once in the previous week. During a median of 5years of follow-up, 1031 patients died, 1147 experienced a major cardiovascular event and 1136 a microvascular event. Compared to patients who undertook no or mild physical activity, those reporting moderate to vigorous activity had a decreased risk of cardiovascular events (HR: 0.78, 95% CI: 0.69-0.88, p<0.0001), microvascular events (HR: 0.85, 95% CI: 0.76-0.96, p=0.010) and all-cause mortality (HR: 0.83, 95% CI: 0.73-0.94, p=0.0044). Conclusions: Moderate to vigorous, but not mild, physical activity is associated with a reduced incidence of cardiovascular events, microvascular complications and all-cause mortality in patients with type 2 diabetes.
KW - Cardiovascular disease
KW - Diabetes complications
KW - Exercise
UR - http://www.scopus.com/inward/record.url?scp=84885316492&partnerID=8YFLogxK
U2 - 10.1111/dom.12122
DO - 10.1111/dom.12122
M3 - Article
C2 - 23675676
AN - SCOPUS:84885316492
SN - 1462-8902
VL - 15
SP - 1008
EP - 1012
JO - Diabetes, Obesity and Metabolism
JF - Diabetes, Obesity and Metabolism
IS - 11
ER -