The influence of parenteral glutamine and branched chain amino acids on total parenteral nutrition-induced atrophy of the gut

Cameron Platell, Rosalie Mccauley, R. Mcculloch, John Hall

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

We tested the hypothesis that the provision of glutamine and branched-chain amino acids would reverse the gut atrophy that accompanies parenteral nutrition. Three hundred seventy-five rats were randomized into 15 groups to receive either conventional parenteral nutrition, rat food, glutamine-enriched parenteral nutrition (0.5% to 2.5%), branched-chain amino acid-enriched parenteral nutrition (0.8% to 2.0%), or glutamine plus branched-chain amino acid-enriched parenteral nutrition (0.5%/0.4% to 1.25%/1/0%). When compared with effects of conventional parenteral nutrition, the infusion of either glutamine or branched-chain amino acids partially reversed, in a dose-dependent manner, atrophy of the small bowel as assessed by gut weight (p <.05), mucosal weight (p <.05), villous height (p <.05), crypt cell production rate (p <.05), and mucosal protein concentration (p <.05). There was no effect on the large bowel. These results suggest that the parenteral infusion of either glutamine or branched-chain amino acids partially reverses the small-bowel atrophy that is associated with the infusion of solutions of conventional parenteral nutrients.
Original languageEnglish
Pages (from-to)348-354
JournalJournal of Parenteral and Enteral Nutrition
Volume17
DOIs
Publication statusPublished - 1993

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Branched Chain Amino Acids
Total Parenteral Nutrition
Parenteral Nutrition
Glutamine
Atrophy
Parenteral Infusions
Fortified Food
Weights and Measures
Food
Proteins

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abstract = "We tested the hypothesis that the provision of glutamine and branched-chain amino acids would reverse the gut atrophy that accompanies parenteral nutrition. Three hundred seventy-five rats were randomized into 15 groups to receive either conventional parenteral nutrition, rat food, glutamine-enriched parenteral nutrition (0.5{\%} to 2.5{\%}), branched-chain amino acid-enriched parenteral nutrition (0.8{\%} to 2.0{\%}), or glutamine plus branched-chain amino acid-enriched parenteral nutrition (0.5{\%}/0.4{\%} to 1.25{\%}/1/0{\%}). When compared with effects of conventional parenteral nutrition, the infusion of either glutamine or branched-chain amino acids partially reversed, in a dose-dependent manner, atrophy of the small bowel as assessed by gut weight (p <.05), mucosal weight (p <.05), villous height (p <.05), crypt cell production rate (p <.05), and mucosal protein concentration (p <.05). There was no effect on the large bowel. These results suggest that the parenteral infusion of either glutamine or branched-chain amino acids partially reverses the small-bowel atrophy that is associated with the infusion of solutions of conventional parenteral nutrients.",
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The influence of parenteral glutamine and branched chain amino acids on total parenteral nutrition-induced atrophy of the gut. / Platell, Cameron; Mccauley, Rosalie; Mcculloch, R.; Hall, John.

In: Journal of Parenteral and Enteral Nutrition, Vol. 17, 1993, p. 348-354.

Research output: Contribution to journalArticle

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