The influence of non-HLA gene polymorphisms and interactions on disease risk in a Western Australian multiple sclerosis cohort

W. Qiu; K. Pham; I.R. James; D.A. Nolan; A.S.L. Castley; Frank Christiansen; P.A. Czarniak; Yuebei Luo; J. Wu; M.J.H. Garlepp; Steve Wilton; Bill Carroll; Francis Mastaglia; Allan Kermode

doi:10.1016/j.jneuroim.2013.04.022

The influence of non-HLA gene polymorphisms and interactions on disease risk in a Western Australian multiple sclerosis cohort

W. Qiu, K. Pham, I.R. James, D.A. Nolan, A.S.L. Castley, Frank Christiansen, P.A. Czarniak, Yuebei Luo, J. Wu, M.J.H. Garlepp, Steve Wilton, Bill Carroll, Francis Mastaglia, Allan Kermode

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Abstract

Non-Human Leukocyte Antigen (HLA) genes have concomitant, although modest, effects on multiple sclerosis (MS) susceptibility; however findings have varied in different populations. Here we present the results of an association study of 16 single nucleotide polymorphisms (SNPs) in 10 non-HLA genes (. IL7R, IL2RA, CLEC-16A, TYK2, CD58, IRF5, STAT3, CTLA-4, APOE, ICAM-1) in a Western Australian cohort of 350 MS patients and 498 population control subjects. Our results indicate that in this population, SNPs in IL7R, TYK2, IRF5 and APOE have modifying effects on MS susceptibility. We also found evidence of interactive protective effects between polymorphisms in the IL7R/. CD58, CLEC-16A/. CTLA-4, and TYK2/. IRF5 genes, which in some instances are restricted within HLA- or gender-defined groups. © 2013 Elsevier B.V.

Original language	English
Pages (from-to)	92-97
Journal	Journal of Neuroimmunology
Volume	261
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2013.04.022
Publication status	Published - 2013

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Qiu, W., Pham, K., James, I. R., Nolan, D. A., Castley, A. S. L., Christiansen, F., Czarniak, P. A., Luo, Y., Wu, J., Garlepp, M. J. H., Wilton, S., Carroll, B., Mastaglia, F., & Kermode, A. (2013). The influence of non-HLA gene polymorphisms and interactions on disease risk in a Western Australian multiple sclerosis cohort. Journal of Neuroimmunology, 261(1-2), 92-97. https://doi.org/10.1016/j.jneuroim.2013.04.022

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title = "The influence of non-HLA gene polymorphisms and interactions on disease risk in a Western Australian multiple sclerosis cohort",

abstract = "Non-Human Leukocyte Antigen (HLA) genes have concomitant, although modest, effects on multiple sclerosis (MS) susceptibility; however findings have varied in different populations. Here we present the results of an association study of 16 single nucleotide polymorphisms (SNPs) in 10 non-HLA genes (. IL7R, IL2RA, CLEC-16A, TYK2, CD58, IRF5, STAT3, CTLA-4, APOE, ICAM-1) in a Western Australian cohort of 350 MS patients and 498 population control subjects. Our results indicate that in this population, SNPs in IL7R, TYK2, IRF5 and APOE have modifying effects on MS susceptibility. We also found evidence of interactive protective effects between polymorphisms in the IL7R/. CD58, CLEC-16A/. CTLA-4, and TYK2/. IRF5 genes, which in some instances are restricted within HLA- or gender-defined groups. {\textcopyright} 2013 Elsevier B.V.",

author = "W. Qiu and K. Pham and I.R. James and D.A. Nolan and A.S.L. Castley and Frank Christiansen and P.A. Czarniak and Yuebei Luo and J. Wu and M.J.H. Garlepp and Steve Wilton and Bill Carroll and Francis Mastaglia and Allan Kermode",

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Qiu, W, Pham, K, James, IR, Nolan, DA, Castley, ASL, Christiansen, F, Czarniak, PA, Luo, Y, Wu, J, Garlepp, MJH, Wilton, S, Carroll, B, Mastaglia, F & Kermode, A 2013, 'The influence of non-HLA gene polymorphisms and interactions on disease risk in a Western Australian multiple sclerosis cohort', Journal of Neuroimmunology, vol. 261, no. 1-2, pp. 92-97. https://doi.org/10.1016/j.jneuroim.2013.04.022

TY - JOUR

T1 - The influence of non-HLA gene polymorphisms and interactions on disease risk in a Western Australian multiple sclerosis cohort

AU - Qiu, W.

AU - Pham, K.

AU - James, I.R.

AU - Nolan, D.A.

AU - Castley, A.S.L.

AU - Christiansen, Frank

AU - Czarniak, P.A.

AU - Luo, Yuebei

AU - Wu, J.

AU - Garlepp, M.J.H.

AU - Wilton, Steve

AU - Carroll, Bill

AU - Mastaglia, Francis

AU - Kermode, Allan

PY - 2013

Y1 - 2013

N2 - Non-Human Leukocyte Antigen (HLA) genes have concomitant, although modest, effects on multiple sclerosis (MS) susceptibility; however findings have varied in different populations. Here we present the results of an association study of 16 single nucleotide polymorphisms (SNPs) in 10 non-HLA genes (. IL7R, IL2RA, CLEC-16A, TYK2, CD58, IRF5, STAT3, CTLA-4, APOE, ICAM-1) in a Western Australian cohort of 350 MS patients and 498 population control subjects. Our results indicate that in this population, SNPs in IL7R, TYK2, IRF5 and APOE have modifying effects on MS susceptibility. We also found evidence of interactive protective effects between polymorphisms in the IL7R/. CD58, CLEC-16A/. CTLA-4, and TYK2/. IRF5 genes, which in some instances are restricted within HLA- or gender-defined groups. © 2013 Elsevier B.V.

AB - Non-Human Leukocyte Antigen (HLA) genes have concomitant, although modest, effects on multiple sclerosis (MS) susceptibility; however findings have varied in different populations. Here we present the results of an association study of 16 single nucleotide polymorphisms (SNPs) in 10 non-HLA genes (. IL7R, IL2RA, CLEC-16A, TYK2, CD58, IRF5, STAT3, CTLA-4, APOE, ICAM-1) in a Western Australian cohort of 350 MS patients and 498 population control subjects. Our results indicate that in this population, SNPs in IL7R, TYK2, IRF5 and APOE have modifying effects on MS susceptibility. We also found evidence of interactive protective effects between polymorphisms in the IL7R/. CD58, CLEC-16A/. CTLA-4, and TYK2/. IRF5 genes, which in some instances are restricted within HLA- or gender-defined groups. © 2013 Elsevier B.V.

U2 - 10.1016/j.jneuroim.2013.04.022

DO - 10.1016/j.jneuroim.2013.04.022

M3 - Article

C2 - 23726763

SN - 0165-5728

VL - 261

SP - 92

EP - 97

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

The influence of non-HLA gene polymorphisms and interactions on disease risk in a Western Australian multiple sclerosis cohort

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