Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 92-97 |
| Journal | Journal of Neuroimmunology |
| Volume | 261 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 2013 |
Fingerprint
Cite this
}
The influence of non-HLA gene polymorphisms and interactions on disease risk in a Western Australian multiple sclerosis cohort. / Qiu, W.; Pham, K.; James, I.R.; Nolan, D.A.; Castley, A.S.L.; Christiansen, Frank; Czarniak, P.A.; Luo, Yuebei; Wu, J.; Garlepp, M.J.H.; Wilton, Steve; Carroll, Bill; Mastaglia, Francis; Kermode, Allan.
In: Journal of Neuroimmunology, Vol. 261, No. 1-2, 2013, p. 92-97.Research output: Contribution to journal › Article
TY - JOUR
T1 - The influence of non-HLA gene polymorphisms and interactions on disease risk in a Western Australian multiple sclerosis cohort
AU - Qiu, W.
AU - Pham, K.
AU - James, I.R.
AU - Nolan, D.A.
AU - Castley, A.S.L.
AU - Christiansen, Frank
AU - Czarniak, P.A.
AU - Luo, Yuebei
AU - Wu, J.
AU - Garlepp, M.J.H.
AU - Wilton, Steve
AU - Carroll, Bill
AU - Mastaglia, Francis
AU - Kermode, Allan
PY - 2013
Y1 - 2013
N2 - Non-Human Leukocyte Antigen (HLA) genes have concomitant, although modest, effects on multiple sclerosis (MS) susceptibility; however findings have varied in different populations. Here we present the results of an association study of 16 single nucleotide polymorphisms (SNPs) in 10 non-HLA genes (. IL7R, IL2RA, CLEC-16A, TYK2, CD58, IRF5, STAT3, CTLA-4, APOE, ICAM-1) in a Western Australian cohort of 350 MS patients and 498 population control subjects. Our results indicate that in this population, SNPs in IL7R, TYK2, IRF5 and APOE have modifying effects on MS susceptibility. We also found evidence of interactive protective effects between polymorphisms in the IL7R/. CD58, CLEC-16A/. CTLA-4, and TYK2/. IRF5 genes, which in some instances are restricted within HLA- or gender-defined groups. © 2013 Elsevier B.V.
AB - Non-Human Leukocyte Antigen (HLA) genes have concomitant, although modest, effects on multiple sclerosis (MS) susceptibility; however findings have varied in different populations. Here we present the results of an association study of 16 single nucleotide polymorphisms (SNPs) in 10 non-HLA genes (. IL7R, IL2RA, CLEC-16A, TYK2, CD58, IRF5, STAT3, CTLA-4, APOE, ICAM-1) in a Western Australian cohort of 350 MS patients and 498 population control subjects. Our results indicate that in this population, SNPs in IL7R, TYK2, IRF5 and APOE have modifying effects on MS susceptibility. We also found evidence of interactive protective effects between polymorphisms in the IL7R/. CD58, CLEC-16A/. CTLA-4, and TYK2/. IRF5 genes, which in some instances are restricted within HLA- or gender-defined groups. © 2013 Elsevier B.V.
U2 - 10.1016/j.jneuroim.2013.04.022
DO - 10.1016/j.jneuroim.2013.04.022
M3 - Article
VL - 261
SP - 92
EP - 97
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -