The influence of modernization and disease on the gastric microbiome of Orang Asli, Myanmars and Modern Malaysians

Eng Guan Chua, Mun Fai Loke, Selva Perumal Gunaletchumy, Han Ming Gan, Kavitha Thevakumar, Chin Yen Tay, Sylvia Young, Than Than Aye, Win Win Maw, Mya Mya Aye, Alex Hwong-Ruey Leow, Ahmad Najib Azmi, Sri Ganesh Kalimuthu, Haji Mohd Akmal Bin Dato Dahlan, Khean Lee Goh, Jamuna Vadivelu

Research output: Contribution to journalArticle

Abstract

The present study explored the differences in gastric microbiome between three distinct populations of Southeast Asia. These include the isolated Orang Asli population and modern Malaysians, as well as patients from Myanmar, the least developed country in the region. All 79 subjects recruited in this study had Helicobacter pylori infection. Based on alpha diversity analysis, Orang Asli had the richest and most diverse gastric microbiome, followed by Myanmar and modern Malaysian groups. Beta diversity analysis revealed significant separation of samples between different populations. These observations are likely to be associated with the level of modernization of each population. Our data further suggested increased bacterial species richness and diversity of the gastric microbiome in individuals who were less modernized, particularly in the Orang Asli group, could suppress the growth of H. pylori. In addition, there were significant variations in the gastric microbiome between modern Malaysians with different types of gastric diseases. Notably, Cutibacteriumacnes was present at significantly greater abundance level in patients with non-ulcerative dyspepsia than those with peptic-ulcer diagnosis. This suggests that C. acnes may also play a role in gastritis besides H. pylori, which merits further investigation.

Original languageEnglish
Article number174
Number of pages13
JournalMicroorganisms
Volume7
Issue number6
DOIs
Publication statusPublished - 14 Jun 2019

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Myanmar
Stomach Diseases
Microbiota
Social Change
Stomach
Helicobacter pylori
Population
Southeastern Asia
Dyspepsia
Acne Vulgaris
Helicobacter Infections
Gastritis
Peptic Ulcer
Developing Countries
Growth

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Chua, Eng Guan ; Loke, Mun Fai ; Gunaletchumy, Selva Perumal ; Gan, Han Ming ; Thevakumar, Kavitha ; Tay, Chin Yen ; Young, Sylvia ; Aye, Than Than ; Maw, Win Win ; Aye, Mya Mya ; Leow, Alex Hwong-Ruey ; Azmi, Ahmad Najib ; Kalimuthu, Sri Ganesh ; Dahlan, Haji Mohd Akmal Bin Dato ; Goh, Khean Lee ; Vadivelu, Jamuna. / The influence of modernization and disease on the gastric microbiome of Orang Asli, Myanmars and Modern Malaysians. In: Microorganisms. 2019 ; Vol. 7, No. 6.
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Chua, EG, Loke, MF, Gunaletchumy, SP, Gan, HM, Thevakumar, K, Tay, CY, Young, S, Aye, TT, Maw, WW, Aye, MM, Leow, AH-R, Azmi, AN, Kalimuthu, SG, Dahlan, HMABD, Goh, KL & Vadivelu, J 2019, 'The influence of modernization and disease on the gastric microbiome of Orang Asli, Myanmars and Modern Malaysians' Microorganisms, vol. 7, no. 6, 174. https://doi.org/10.3390/microorganisms7060174

The influence of modernization and disease on the gastric microbiome of Orang Asli, Myanmars and Modern Malaysians. / Chua, Eng Guan; Loke, Mun Fai; Gunaletchumy, Selva Perumal; Gan, Han Ming; Thevakumar, Kavitha; Tay, Chin Yen; Young, Sylvia; Aye, Than Than; Maw, Win Win; Aye, Mya Mya; Leow, Alex Hwong-Ruey; Azmi, Ahmad Najib; Kalimuthu, Sri Ganesh; Dahlan, Haji Mohd Akmal Bin Dato; Goh, Khean Lee; Vadivelu, Jamuna.

In: Microorganisms, Vol. 7, No. 6, 174, 14.06.2019.

Research output: Contribution to journalArticle

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T1 - The influence of modernization and disease on the gastric microbiome of Orang Asli, Myanmars and Modern Malaysians

AU - Chua, Eng Guan

AU - Loke, Mun Fai

AU - Gunaletchumy, Selva Perumal

AU - Gan, Han Ming

AU - Thevakumar, Kavitha

AU - Tay, Chin Yen

AU - Young, Sylvia

AU - Aye, Than Than

AU - Maw, Win Win

AU - Aye, Mya Mya

AU - Leow, Alex Hwong-Ruey

AU - Azmi, Ahmad Najib

AU - Kalimuthu, Sri Ganesh

AU - Dahlan, Haji Mohd Akmal Bin Dato

AU - Goh, Khean Lee

AU - Vadivelu, Jamuna

PY - 2019/6/14

Y1 - 2019/6/14

N2 - The present study explored the differences in gastric microbiome between three distinct populations of Southeast Asia. These include the isolated Orang Asli population and modern Malaysians, as well as patients from Myanmar, the least developed country in the region. All 79 subjects recruited in this study had Helicobacter pylori infection. Based on alpha diversity analysis, Orang Asli had the richest and most diverse gastric microbiome, followed by Myanmar and modern Malaysian groups. Beta diversity analysis revealed significant separation of samples between different populations. These observations are likely to be associated with the level of modernization of each population. Our data further suggested increased bacterial species richness and diversity of the gastric microbiome in individuals who were less modernized, particularly in the Orang Asli group, could suppress the growth of H. pylori. In addition, there were significant variations in the gastric microbiome between modern Malaysians with different types of gastric diseases. Notably, Cutibacteriumacnes was present at significantly greater abundance level in patients with non-ulcerative dyspepsia than those with peptic-ulcer diagnosis. This suggests that C. acnes may also play a role in gastritis besides H. pylori, which merits further investigation.

AB - The present study explored the differences in gastric microbiome between three distinct populations of Southeast Asia. These include the isolated Orang Asli population and modern Malaysians, as well as patients from Myanmar, the least developed country in the region. All 79 subjects recruited in this study had Helicobacter pylori infection. Based on alpha diversity analysis, Orang Asli had the richest and most diverse gastric microbiome, followed by Myanmar and modern Malaysian groups. Beta diversity analysis revealed significant separation of samples between different populations. These observations are likely to be associated with the level of modernization of each population. Our data further suggested increased bacterial species richness and diversity of the gastric microbiome in individuals who were less modernized, particularly in the Orang Asli group, could suppress the growth of H. pylori. In addition, there were significant variations in the gastric microbiome between modern Malaysians with different types of gastric diseases. Notably, Cutibacteriumacnes was present at significantly greater abundance level in patients with non-ulcerative dyspepsia than those with peptic-ulcer diagnosis. This suggests that C. acnes may also play a role in gastritis besides H. pylori, which merits further investigation.

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DO - 10.3390/microorganisms7060174

M3 - Article

VL - 7

JO - Microorganisms

JF - Microorganisms

SN - 2076-2607

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