Veins, ore deposits and faults are often spatially related. We quantitatively explore the coupled faulting-deformation-fluid flow-chemical reaction process resulting in this association. Our 2D numerical models focus on faulting-related deformation, dilation and permeability development, fluid flow patterns, and fluid focusing/mixing locations. The models provide insight into the transport of fluids through low-permeability rocks with isolated, but more permeable faults. Mineral precipitation patterns resulting from chemical reactions during the coupled processes are also computed. The results are relevant to understanding the relationship of gold ore deposits to faults.