The Influence of a Positive Empathetic Interaction on Conditioned Pain Modulation and Manipulation Induced Analgesia in People with Lateral Epicondylalgia

Ahmad Muhsen, Penny Moss, William Gibson, Bruce Walker, Angela Jacques, Stephan Schug, Anthony Wright

Research output: Contribution to journalArticle


OBJECTIVE: Conditioned pain modulation (CPM) and manipulation induced analgesia (MIA) are two forms of endogenous analgesia. Many forms of analgesia can be influenced by the nature of the patient clinician interaction. The aim of this study was to evaluate the influence of an empathetic and supportive interaction on CPM and MIA in people with Lateral Epicondylalgia (LE).

METHODS: In a double-blind, randomised, controlled trial, 68 participants with LE were assigned to two groups: the empathetic and neutral interaction groups. The interactions were carried out by a trained, professional role play actor, playing the part of a research assistant (RA). The RA actor spent 15min prior to CPM and MIA assessment interacting with the participants in an empathetic or neutral manner. Immediately after the interaction, a blinded assessor measured pressure pain threshold (PPT) at the symptomatic elbow and ipsilateral wrist during CPM and MIA testing. Linear mixed models were used to evaluate differences in CPM and MIA responses between the interaction groups.

RESULTS: There was a significant difference in CARE scores between the groups (P

DISCUSSION: A single session of empathetic interaction positively influenced both CPM and MIA responses in people with LE.

Original languageEnglish
JournalThe Clinical Journal of Pain
Publication statusE-pub ahead of print - 19 Feb 2020


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