The incidence of cancer recurrence and new cancer following commencement of dialysis

Wai H. Lim, Esther Ooi, Aashi Pankaj, Armando Teixeira-Pinto, Yingxin Lin, David W. Johnson, Carmel M. Hawley, Andrea K. Viecelli, Helen Pilmore, Matthew A. Roberts, Christopher E. Davies, Anoushka Krishnan, Germaine Wong

Research output: Contribution to journalArticlepeer-review

Abstract

Background Patients with kidney failure have a higher cancer risk compared with the age-matched general population. However, the outcomes of incident dialysis patients with a prior cancer history are unknown. Methods Using Australia and New Zealand Dialysis and Transplant Registry data (2000-2019), the outcomes and survival probabilities of incident dialysis patients with prior cancers and having experienced a cancer recurrence or having developed a new cancer after dialysis commencement were described. Results Of 4912 patients with prior cancers before dialysis commencement, 323 (7%) and 343 (7%) patients experienced cancer recurrence or developed new cancers after dialysis initiation, respectively. The median time from dialysis commencement to cancer recurrence was 1.2 years [interquartile range (IQR) 0.5-2.8] and was 2.0 years (IQR 0.7-4.0) for new cancer occurrence. Of those with cancer recurrence, 80% presented with metastatic disease and one in two patients died from cancer, with a median time from cancer recurrence to death of 0.5 years (IQR 0.2-1.7). Of those who developed new cancer, urinary tract and respiratory cancers were the most frequent cancer types, with a median time from new cancer diagnosis to death of 1.3 years (IQR 0.4-3.1). The 3-year survival probabilities on dialysis following cancer recurrence and new cancer were 19% [95% confidence interval (CI) 15-24] and 41% (35-47), respectively. Conclusion Among incident dialysis patients with a prior cancer history, 14% experienced cancer recurrence or developed a new cancer. Patients who experienced cancer recurrence or developed new cancer have poor outcomes, with
Original languageEnglish
Pages (from-to)1770-1781
Number of pages12
JournalClinical Kidney Journal
Volume15
Issue number9
Early online date2 Jun 2022
DOIs
Publication statusPublished - 1 Sep 2022

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