The Implications of DNA Methylation on Food Allergy

Research output: Contribution to journalReview article

  • 1 Citations

Abstract

Food allergy is a major clinical and public health concern worldwide. The risk factors are well defined, however, the mechanisms by which they affect immune development remain largely unknown, and unfortunately the effective treatment or prevention of food allergy is still being researched. Recent studies show that the genes that are critical for the development of food allergy are regulated through DNA methylation. Environmental factors can affect host DNA methylation status and subsequently predispose people to food allergy. DNA methylation is therefore an important mediator of gene-environment interactions in food allergy and key to understanding the mechanisms underlying the allergic development. Indeed, the modification and identification of the methylation levels of specific genetic loci have gained increasing attention for therapeutic and diagnostic application in combating food allergy. In this review, we summarize and discuss the recent developments of DNA methylation in food allergy, including the patho-genesis, therapy, and diagnosis. This review will also summarize and discuss the environmental factors that affect DNA methylation levels in food allergy.

LanguageEnglish
Pages183-192
Number of pages10
JournalInternational Archives of Allergy and Immunology
Volume173
Issue number4
DOIs
StatePublished - 1 Sep 2017

Fingerprint

Food Hypersensitivity
DNA Methylation
Gene-Environment Interaction
Genetic Loci
Methylation
Public Health
Therapeutics

Cite this

@article{8f24bb8f62254fe69f430f8a6c473a1c,
title = "The Implications of DNA Methylation on Food Allergy",
abstract = "Food allergy is a major clinical and public health concern worldwide. The risk factors are well defined, however, the mechanisms by which they affect immune development remain largely unknown, and unfortunately the effective treatment or prevention of food allergy is still being researched. Recent studies show that the genes that are critical for the development of food allergy are regulated through DNA methylation. Environmental factors can affect host DNA methylation status and subsequently predispose people to food allergy. DNA methylation is therefore an important mediator of gene-environment interactions in food allergy and key to understanding the mechanisms underlying the allergic development. Indeed, the modification and identification of the methylation levels of specific genetic loci have gained increasing attention for therapeutic and diagnostic application in combating food allergy. In this review, we summarize and discuss the recent developments of DNA methylation in food allergy, including the patho-genesis, therapy, and diagnosis. This review will also summarize and discuss the environmental factors that affect DNA methylation levels in food allergy.",
keywords = "DNA methylation, Food allergy, Gene expression, Gene-environment interactions",
author = "Lee, {Khui Hung} and Yong Song and Michael O'Sullivan and Gavin Pereira and Richard Loh and Guicheng Zhang",
year = "2017",
month = "9",
day = "1",
doi = "10.1159/000479513",
language = "English",
volume = "173",
pages = "183--192",
journal = "International Archives of Allergy and Immunology",
issn = "1018-2438",
publisher = "S Karger AG",
number = "4",

}

The Implications of DNA Methylation on Food Allergy. / Lee, Khui Hung; Song, Yong; O'Sullivan, Michael; Pereira, Gavin; Loh, Richard; Zhang, Guicheng.

In: International Archives of Allergy and Immunology, Vol. 173, No. 4, 01.09.2017, p. 183-192.

Research output: Contribution to journalReview article

TY - JOUR

T1 - The Implications of DNA Methylation on Food Allergy

AU - Lee,Khui Hung

AU - Song,Yong

AU - O'Sullivan,Michael

AU - Pereira,Gavin

AU - Loh,Richard

AU - Zhang,Guicheng

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Food allergy is a major clinical and public health concern worldwide. The risk factors are well defined, however, the mechanisms by which they affect immune development remain largely unknown, and unfortunately the effective treatment or prevention of food allergy is still being researched. Recent studies show that the genes that are critical for the development of food allergy are regulated through DNA methylation. Environmental factors can affect host DNA methylation status and subsequently predispose people to food allergy. DNA methylation is therefore an important mediator of gene-environment interactions in food allergy and key to understanding the mechanisms underlying the allergic development. Indeed, the modification and identification of the methylation levels of specific genetic loci have gained increasing attention for therapeutic and diagnostic application in combating food allergy. In this review, we summarize and discuss the recent developments of DNA methylation in food allergy, including the patho-genesis, therapy, and diagnosis. This review will also summarize and discuss the environmental factors that affect DNA methylation levels in food allergy.

AB - Food allergy is a major clinical and public health concern worldwide. The risk factors are well defined, however, the mechanisms by which they affect immune development remain largely unknown, and unfortunately the effective treatment or prevention of food allergy is still being researched. Recent studies show that the genes that are critical for the development of food allergy are regulated through DNA methylation. Environmental factors can affect host DNA methylation status and subsequently predispose people to food allergy. DNA methylation is therefore an important mediator of gene-environment interactions in food allergy and key to understanding the mechanisms underlying the allergic development. Indeed, the modification and identification of the methylation levels of specific genetic loci have gained increasing attention for therapeutic and diagnostic application in combating food allergy. In this review, we summarize and discuss the recent developments of DNA methylation in food allergy, including the patho-genesis, therapy, and diagnosis. This review will also summarize and discuss the environmental factors that affect DNA methylation levels in food allergy.

KW - DNA methylation

KW - Food allergy

KW - Gene expression

KW - Gene-environment interactions

UR - http://www.scopus.com/inward/record.url?scp=85028752475&partnerID=8YFLogxK

U2 - 10.1159/000479513

DO - 10.1159/000479513

M3 - Review article

VL - 173

SP - 183

EP - 192

JO - International Archives of Allergy and Immunology

T2 - International Archives of Allergy and Immunology

JF - International Archives of Allergy and Immunology

SN - 1018-2438

IS - 4

ER -