The impact of water quality on the development of the infant gut microbiome: a randomised controlled trial

Kim Parkin

doi:10.26182/jc05-3p87

The impact of water quality on the development of the infant gut microbiome: a randomised controlled trial

Kim Parkin

UWA Medical School

Research output: Thesis › Doctoral Thesis

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Abstract

The gut microbiome is easily influenced by environmental factors until three years of age. Chlorine has antimicrobial properties making domestic water quality a potential risk factor for gut dysbiosis. We conducted a randomised controlled trial investigating the impact of water quality by comparing longitudinal changes in the gut microbiome from six- to eighteen-months of age. While overall microbiome diversity was unaffected, infants receiving chlorinated water showed increased abundance of antibiotic resistance pathways. The many public health benefits of water chlorination outweigh the risks, however, further studies on the long-term health impacts of chlorinated drinking water are required

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Martino, David, Supervisor Verhasselt, Valerie, Supervisor Christophersen, Claus T., Supervisor, External person Cooper, Matthew, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	15 Oct 2024
DOIs	https://doi.org/10.26182/jc05-3p87
Publication status	Unpublished - 2024

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10.26182/jc05-3p87

THESIS - DOCTOR OF PHILOSOPHY - PARKIN Kimberley - 2024
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1 Article
1 Review article

Metagenomic Characterisation of the Gut Microbiome and Effect of Complementary Feeding on Bifidobacterium spp. in Australian Infants
Parkin, K., Palmer, D. J., Verhasselt, V., Amenyogbe, N., Cooper, M. N., Christophersen, C. T., Prescott, S. L., Silva, D. & Martino, D., 22 Jan 2024, In: Microorganisms. 12, 1, 16 p., 228.
Research output: Contribution to journal › Article › peer-review

Open Access
2 Citations (Scopus)
Risk factors for gut dysbiosis in early life
Parkin, K., Christophersen, C. T., Verhasselt, V., Cooper, M. N. & Martino, D., Oct 2021, In: Microorganisms. 9, 10, 2066.
Research output: Contribution to journal › Review article › peer-review

Open Access
35 Citations (Scopus)

Cite this

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title = "The impact of water quality on the development of the infant gut microbiome: a randomised controlled trial",

abstract = "The gut microbiome is easily influenced by environmental factors until three years of age. Chlorine has antimicrobial properties making domestic water quality a potential risk factor for gut dysbiosis. We conducted a randomised controlled trial investigating the impact of water quality by comparing longitudinal changes in the gut microbiome from six- to eighteen-months of age. While overall microbiome diversity was unaffected, infants receiving chlorinated water showed increased abundance of antibiotic resistance pathways. The many public health benefits of water chlorination outweigh the risks, however, further studies on the long-term health impacts of chlorinated drinking water are required",

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AB - The gut microbiome is easily influenced by environmental factors until three years of age. Chlorine has antimicrobial properties making domestic water quality a potential risk factor for gut dysbiosis. We conducted a randomised controlled trial investigating the impact of water quality by comparing longitudinal changes in the gut microbiome from six- to eighteen-months of age. While overall microbiome diversity was unaffected, infants receiving chlorinated water showed increased abundance of antibiotic resistance pathways. The many public health benefits of water chlorination outweigh the risks, however, further studies on the long-term health impacts of chlorinated drinking water are required

KW - Infant microbiota

KW - water quality

KW - water chlorination

KW - disinfection by-products

KW - whole genome shotgun metagenomics

KW - antibiotic resistance

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M3 - Doctoral Thesis

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The impact of water quality on the development of the infant gut microbiome: a randomised controlled trial

Abstract

UN SDGs

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Research output

Metagenomic Characterisation of the Gut Microbiome and Effect of Complementary Feeding on Bifidobacterium spp. in Australian Infants

Risk factors for gut dysbiosis in early life

Cite this