The impact of pneumococcal vaccines on carriage density in children at risk of otitis media and pneumonia: Development, optimisation and application of accurate molecular tools

Camilla de Gier

Research output: ThesisDoctoral Thesis

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Abstract

Respiratory infections, including pneumonia and otitis media, are the most under 5 common cause of illness and mortality in children years of age. Bacterial colonisation of the nasopharynx always precedes disease and increased nasopharyngeal density of pathogens has been shown to correlate with the onset of disease. This thesis explored the link between specific bacterial nasopharyngeal density and disease susceptibility, and impact of pneumococcal vaccination on bacterial carriage density. While nasopharyngeal density measurements may not be suitable as a standalone diagnostic tool, it is useful as a surveillance tool to assess the impact of targeted therapies, such as vaccines.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Award date2 Oct 2019
DOIs
Publication statusUnpublished - 2019

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