Matemal obesity induces pregnancy complications and disturbs fetal development, but the specific mechanisms underlying these effects are unclear. Circadian rhythms are involved in maternal adaptations to pregnancy and metabolic complications associated with obesity. Accordingly, obesity-induced circadian dysfunction may drive adverse outcomes in obese pregnancy. This thesis examined the effects of obesity on rhythmic gene expression in maternal, placental and fetal tissues in the rat. It was found that obesity disturbed clock gene expression In maternal metabolic tissues and altered rhythmic hormone profiles. There was relatively little impact on fetal and placental clock gene expression, possibly indicative of immature circadian development.
|Qualification||Doctor of Philosophy|
|Award date||24 Jan 2017|
|Publication status||Unpublished - 2016|