The impact of obesity on circadian rhythms in the mother, placenta and fetus in rat pregnancy

    Research output: ThesisDoctoral Thesis

    477 Downloads (Pure)

    Abstract

    Matemal obesity induces pregnancy complications and disturbs fetal development, but the specific mechanisms underlying these effects are unclear. Circadian rhythms are involved in maternal adaptations to pregnancy and metabolic complications associated with obesity. Accordingly, obesity-induced circadian dysfunction may drive adverse outcomes in obese pregnancy. This thesis examined the effects of obesity on rhythmic gene expression in maternal, placental and fetal tissues in the rat. It was found that obesity disturbed clock gene expression In maternal metabolic tissues and altered rhythmic hormone profiles. There was relatively little impact on fetal and placental clock gene expression, possibly indicative of immature circadian development.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    Award date24 Jan 2017
    Publication statusUnpublished - 2016

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