Arterial inflammation has a central role in cardiovascular disease. Antenatal steroid treatment could potentially be used to ameliorate the effects of inflammation in the early-life period. This thesis aimed to determine the biomechanical impact of inflammation on the aorta in lambs with systemic inflammation as well as that of postnatal anti-inflammatory treatment. Antenatally induced inflammation increased arterial stiffness, while postnatal dexamethasone treatment returned stiffness to levels comparable to controls. Postnatal dexamethasone alone was itself associated with increased arterial stiffness. This thesis reveals important structural implications of early-life inflammation and supports a case for the management of preterm inflammatory conditions.
|Qualification||Doctor of Philosophy|
|Award date||23 Feb 2020|
|Publication status||Unpublished - 2020|