[Truncated abstract] Objective The purpose of this study was to examine whether exercise training enhances microvascular function in adolescents with type 2 diabetes mellitus (T2DM). Background Endothelium-derived nitric oxide (NO) has many anti-atherogenic effects. Regular exercise improves physical fitness and glycaemic control in patients with T2DM, thereby increasing NO stimulation, hence enhancing vascular function and reducing cardiovascular risk. This study examined the effect of 12 weeks of exercise training and detraining on microvascular function in adolescents with T2DM. Methods Nine T2DM adolescents were divided into 2 groups; exercised (n = 6) and controls (n = 3). Microvascular function was assessed in the forearm skin by laser Doppler flowmetry, combined with microdialysis for infusions of Ringer's solution or LNMMA, a nitric oxide (NO) blocker. Differences between the two microdialysis sites in terms of cutaneous vascular conductance (CVC) provided an index of microvascular endothelial-dependent NO function. The glycaemic clamp technique ensured blood glucose levels were maintained at 4.5 - 6.0 mmol/L during all testing sessions...
|Publication status||Unpublished - 2012|