The impact of disrupted mitochondrial gene expression on mitochondrial translation, energy homeostasis and disease

Research output: ThesisDoctoral Thesis

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Abstract

Disturbances to mitochondrial function have been implicated in many human diseases. In my research, I developed in vitro and in vivo models of disrupted mitochondrial gene expression to investigate and identify mechanisms triggering mitochondrial dysfunction and disease. I showed that proteins involved in membrane transport, stress signaling, and mitochondrial RNA-binding are essential for the productivity of the mitochondrial respiratory complexes and the maintenance of healthy cellular function. I have demonstrated how defects in these mechanisms drive cellular dysfunction and their key role in human disease pathogenesis.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Filipovska, Aleksandra, Supervisor
  • Richman, Tara, Supervisor
Thesis sponsors
Award date5 Feb 2024
DOIs
Publication statusUnpublished - 2023

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