The impact of antimicrobial resistance on induction, transmission and treatment of Clostridium difficile infection

Stacey Hong, Daniel R. Knight, Thomas Riley

Research output: Contribution to journalArticle


Clostridium difficile infection (CDI) of the gastrointestinal (GI) tract is a potentially life-threatening disease that has surpassed multi-drug-resistant Staphylococcus aureus as the commonest antimicrobial-resistant organism associated with healthcare(1). This obligate anaerobic spore-forming Gram-positive bacillus colonises the GI tract and its numbers increase after disruption of the commensal GI microbiota often induced by exposure to antimicrobial agents(2). Paradoxically, the disease that may follow its outgrowth necessitates further antimicrobial treatment. Already a major challenge to infection prevention and control strategies, there are indications that C. difficile is developing further resistance to currently used antimicrobial agents.

Original languageEnglish
Pages (from-to)77-81
Number of pages5
JournalMicrobiology Australia
Issue number2
Publication statusPublished - May 2019

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