The Immunobiology of the Serine Protease Allergens from the House Dust

Geoffrey Stewart, S.M. Boyd, C.H. Bird, K.D. Krska, M.R. Kollinger, P.J. Thompson

    Research output: Contribution to journalArticlepeer-review

    35 Citations (Scopus)


    Extracts of Dermatophagoides pteronyssinus and D. farinae were shown to contain a variety of 30 kDA serine proteases, including trypsin, chymotrypsin, and an elastase-like enzyme. The mite trypsin, unlike chymotrypsin and the elastase enzyme, was heterogeneous with regard to charge. The enzymes were shown to be present at higher concentration in fecally enriched extracts than in whole mite extracts. The proteases were shown to induce vascular permeability and to detach cells in tissue culture. Further study showed that the mite elastase induced non-IgE mediated rat mast cell degranulation. Such properties may contribute to immunogenicity. (C) 1994 Wiley-Liss, Inc.
    Original languageEnglish
    Pages (from-to)105-107
    JournalAmerican Journal of Industrial Medicine
    Publication statusPublished - 1994


    Dive into the research topics of 'The Immunobiology of the Serine Protease Allergens from the House Dust'. Together they form a unique fingerprint.

    Cite this