The in situ profile of GCTM-5 expression in liver disease and malignancy: computer analysis and prognostication

Anne Kramer

Research output: ThesisDoctoral Thesis

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Abstract

Hepatic progenitor cells (HPCs) are important in liver pathologies and hepatocellular carcinoma (HCC). GCTM-5, a marker of HPCs, is a new candidate prognostic biomarker. The thesis develops a semi-computerised approach using the software "InForm" to quantify the HPC response and assess liver disease severity using custom algorithms. The frequency of GCTM-5+ve cells were associated with necroinflammation in acute hepatitis (r2=0.7362, p-value less than 0.01), and with clinical outcomes in HCC (p-value less than 0.05). This study establishes GCTM-5 as a prognostic biomarker of interest in acute hepatitis and HCC. Further studies are warranted to authenticate its prognostic utility in a large longitudinal cohort.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Thesis sponsors
Award date6 May 2019
DOIs
Publication statusUnpublished - 2019

Take-down notice

Embargoed from 06/05/2019 to 06/05/2020
Made publicly available on 06/05/2020

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