The identification and characterisation of a novel null HLA-DRB1 allele

S.J. Fidler; L.K. Smith; Frank Christiansen

doi:10.1111/j.1399-0039.2006.760_3.x

The identification and characterisation of a novel null HLA-DRB1 allele

S.J. Fidler, L.K. Smith, Frank Christiansen

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

Since the introduction of DNA-based human leukocyte antigen (HLA) typing a number of discrepancies with serological typing have been documented. At the time of submission of this abstract (July 2005 ImMunoGeneTics project (IMGT) project database release) 42 HLA class I and II null alleles had been described characterised by a lack of expression of cell surface antigen. These null alleles can be accounted for by a number of demonstrated molecular mechanisms including insertion, deletion and point mutation and may lead to a nonsense codon, splicing defect or premature stop codon.

Original language	English
Pages (from-to)	58-60
Journal	Tissue Antigens
Volume	69
Issue number	Supplement 1
DOIs	https://doi.org/10.1111/j.1399-0039.2006.760_3.x
Publication status	Published - 2007

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title = "The identification and characterisation of a novel null HLA-DRB1 allele",

abstract = "Since the introduction of DNA-based human leukocyte antigen (HLA) typing a number of discrepancies with serological typing have been documented. At the time of submission of this abstract (July 2005 ImMunoGeneTics project (IMGT) project database release) 42 HLA class I and II null alleles had been described characterised by a lack of expression of cell surface antigen. These null alleles can be accounted for by a number of demonstrated molecular mechanisms including insertion, deletion and point mutation and may lead to a nonsense codon, splicing defect or premature stop codon.",

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AU - Fidler, S.J.

AU - Smith, L.K.

AU - Christiansen, Frank

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N2 - Since the introduction of DNA-based human leukocyte antigen (HLA) typing a number of discrepancies with serological typing have been documented. At the time of submission of this abstract (July 2005 ImMunoGeneTics project (IMGT) project database release) 42 HLA class I and II null alleles had been described characterised by a lack of expression of cell surface antigen. These null alleles can be accounted for by a number of demonstrated molecular mechanisms including insertion, deletion and point mutation and may lead to a nonsense codon, splicing defect or premature stop codon.

AB - Since the introduction of DNA-based human leukocyte antigen (HLA) typing a number of discrepancies with serological typing have been documented. At the time of submission of this abstract (July 2005 ImMunoGeneTics project (IMGT) project database release) 42 HLA class I and II null alleles had been described characterised by a lack of expression of cell surface antigen. These null alleles can be accounted for by a number of demonstrated molecular mechanisms including insertion, deletion and point mutation and may lead to a nonsense codon, splicing defect or premature stop codon.

U2 - 10.1111/j.1399-0039.2006.760_3.x

DO - 10.1111/j.1399-0039.2006.760_3.x

M3 - Review article

C2 - 17445166

SN - 0001-2815

VL - 69

SP - 58

EP - 60

JO - Tissue Antigens

JF - Tissue Antigens

IS - Supplement 1

ER -

The identification and characterisation of a novel null HLA-DRB1 allele

Abstract

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