The identification and characterisation of a novel null HLA-DRB1 allele

S.J. Fidler, L.K. Smith, Frank Christiansen

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Since the introduction of DNA-based human leukocyte antigen (HLA) typing a number of discrepancies with serological typing have been documented. At the time of submission of this abstract (July 2005 ImMunoGeneTics project (IMGT) project database release) 42 HLA class I and II null alleles had been described characterised by a lack of expression of cell surface antigen. These null alleles can be accounted for by a number of demonstrated molecular mechanisms including insertion, deletion and point mutation and may lead to a nonsense codon, splicing defect or premature stop codon.
Original languageEnglish
Pages (from-to)58-60
JournalTissue Antigens
Volume69
Issue numberSupplement 1
DOIs
Publication statusPublished - 2007

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