The identification and characterisation of a novel null HLA-DRB1 allele

S.J. Fidler, L.K. Smith, Frank Christiansen

    Research output: Contribution to journalReview articlepeer-review

    2 Citations (Scopus)


    Since the introduction of DNA-based human leukocyte antigen (HLA) typing a number of discrepancies with serological typing have been documented. At the time of submission of this abstract (July 2005 ImMunoGeneTics project (IMGT) project database release) 42 HLA class I and II null alleles had been described characterised by a lack of expression of cell surface antigen. These null alleles can be accounted for by a number of demonstrated molecular mechanisms including insertion, deletion and point mutation and may lead to a nonsense codon, splicing defect or premature stop codon.
    Original languageEnglish
    Pages (from-to)58-60
    JournalTissue Antigens
    Issue numberSupplement 1
    Publication statusPublished - 2007


    Dive into the research topics of 'The identification and characterisation of a novel null HLA-DRB1 allele'. Together they form a unique fingerprint.

    Cite this