The genetic associations of acute anterior uveitis and their overlap with the genetics of ankylosing spondylitis

P.C. Robinson; P.J. Leo; J.J. Pointon; J. Harris; K. Cremin; L.A. Bradbury; P. Donnelly; I. Barroso; J.M. Blackwell; E. Bramon; M.A. Brown; J.P. Casas; A. Corvin; P. Deloukas; A. Duncanson; J. Jankowski; H.S. Markus; C.G. Mathew; C.N.A. Palmer; R. Plomin; A. Rautanen; S.J. Sawcer; R.C. Trembath; A.C. Viswanathan; N.W. Wood; C.C.A. Spencer; G. Band; C. Bellenguez; C. Freeman; G. Hellenthal; E. Giannoulatou; M. Pirinen; R. Pearson; A. Strange; Z. Su; D. Vukcevic; C. Langford; S.E. Hunt; S. Edkins; R. Gwilliam; H. Blackburn; S.J. Bumpstead; S. Dronov; M. Gillman; E. Gray; N. Hammond; A. Jayakumar; O.T. Mccann; J. Liddle; S.C. Potter; R. Ravindrarajah; M. Ricketts; M. Waller; P. Weston; S. Widaa; P. Whittaker; E. Mccloskey; J. Eisman; G. Jones; G. Nicholson; R. Eastell; P. Sambrook; Richard Prince; E. Dennison; I. Reid; J. Wark; S. Stebbings; A.A. Harrison; D.M. Evans; E.L. Duncan; B.P. Wordsworth

doi:10.1038/gene.2015.49

The genetic associations of acute anterior uveitis and their overlap with the genetics of ankylosing spondylitis

P.C. Robinson, P.J. Leo, J.J. Pointon, J. Harris, K. Cremin, L.A. Bradbury, P. Donnelly, I. Barroso, J.M. Blackwell, E. Bramon, M.A. Brown, J.P. Casas, A. Corvin, P. Deloukas, A. Duncanson, J. Jankowski, H.S. Markus, C.G. Mathew, C.N.A. Palmer, R. PlominA. Rautanen, S.J. Sawcer, R.C. Trembath, A.C. Viswanathan, N.W. Wood, C.C.A. Spencer, G. Band, C. Bellenguez, C. Freeman, G. Hellenthal, E. Giannoulatou, M. Pirinen, R. Pearson, A. Strange, Z. Su, D. Vukcevic, C. Langford, S.E. Hunt, S. Edkins, R. Gwilliam, H. Blackburn, S.J. Bumpstead, S. Dronov, M. Gillman, E. Gray, N. Hammond, A. Jayakumar, O.T. Mccann, J. Liddle, S.C. Potter, R. Ravindrarajah, M. Ricketts, M. Waller, P. Weston, S. Widaa, P. Whittaker, E. Mccloskey, J. Eisman, G. Jones, G. Nicholson, R. Eastell, P. Sambrook, Richard Prince, E. Dennison, I. Reid, J. Wark, S. Stebbings, A.A. Harrison, D.M. Evans, E.L. Duncan, B.P. Wordsworth

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Abstract

© 2016 Macmillan Publishers Limited All rights reserved. Acute anterior uveitis (AAU) involves inflammation of the iris and ciliary body of the eye. It occurs both in isolation and as a complication of ankylosing spondylitis (AS). It is strongly associated with HLA-B∗27, but previous studies have suggested that further genetic factors may confer additional risk. We sought to investigate this using the Illumina Exomechip microarray, to compare 1504 cases with AS and AAU, 1805 with AS but no AAU and 21 133 healthy controls. We also used a heterogeneity test to test the differences in effect size between AS with AAU and AS without AAU. In the analysis comparing AS+AAU+ cases versus controls, HLA-B∗27 and HLA-A∗02:01 were significantly associated with the presence of AAU (P

Original language	English
Pages (from-to)	46-51
Number of pages	6
Journal	Genes and Immunity
Volume	17
Issue number	1
DOIs	https://doi.org/10.1038/gene.2015.49
Publication status	Published - 1 Jan 2016

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Robinson, P. C., Leo, P. J., Pointon, J. J., Harris, J., Cremin, K., Bradbury, L. A., Donnelly, P., Barroso, I., Blackwell, J. M., Bramon, E., Brown, M. A., Casas, J. P., Corvin, A., Deloukas, P., Duncanson, A., Jankowski, J., Markus, H. S., Mathew, C. G., Palmer, C. N. A., ... Wordsworth, B. P. (2016). The genetic associations of acute anterior uveitis and their overlap with the genetics of ankylosing spondylitis. Genes and Immunity, 17(1), 46-51. https://doi.org/10.1038/gene.2015.49

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abstract = "{\textcopyright} 2016 Macmillan Publishers Limited All rights reserved. Acute anterior uveitis (AAU) involves inflammation of the iris and ciliary body of the eye. It occurs both in isolation and as a complication of ankylosing spondylitis (AS). It is strongly associated with HLA-B∗27, but previous studies have suggested that further genetic factors may confer additional risk. We sought to investigate this using the Illumina Exomechip microarray, to compare 1504 cases with AS and AAU, 1805 with AS but no AAU and 21 133 healthy controls. We also used a heterogeneity test to test the differences in effect size between AS with AAU and AS without AAU. In the analysis comparing AS+AAU+ cases versus controls, HLA-B∗27 and HLA-A∗02:01 were significantly associated with the presence of AAU (P",

author = "P.C. Robinson and P.J. Leo and J.J. Pointon and J. Harris and K. Cremin and L.A. Bradbury and P. Donnelly and I. Barroso and J.M. Blackwell and E. Bramon and M.A. Brown and J.P. Casas and A. Corvin and P. Deloukas and A. Duncanson and J. Jankowski and H.S. Markus and C.G. Mathew and C.N.A. Palmer and R. Plomin and A. Rautanen and S.J. Sawcer and R.C. Trembath and A.C. Viswanathan and N.W. Wood and C.C.A. Spencer and G. Band and C. Bellenguez and C. Freeman and G. Hellenthal and E. Giannoulatou and M. Pirinen and R. Pearson and A. Strange and Z. Su and D. Vukcevic and C. Langford and S.E. Hunt and S. Edkins and R. Gwilliam and H. Blackburn and S.J. Bumpstead and S. Dronov and M. Gillman and E. Gray and N. Hammond and A. Jayakumar and O.T. Mccann and J. Liddle and S.C. Potter and R. Ravindrarajah and M. Ricketts and M. Waller and P. Weston and S. Widaa and P. Whittaker and E. Mccloskey and J. Eisman and G. Jones and G. Nicholson and R. Eastell and P. Sambrook and Richard Prince and E. Dennison and I. Reid and J. Wark and S. Stebbings and A.A. Harrison and D.M. Evans and E.L. Duncan and B.P. Wordsworth",

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Robinson, PC, Leo, PJ, Pointon, JJ, Harris, J, Cremin, K, Bradbury, LA, Donnelly, P, Barroso, I, Blackwell, JM, Bramon, E, Brown, MA, Casas, JP, Corvin, A, Deloukas, P, Duncanson, A, Jankowski, J, Markus, HS, Mathew, CG, Palmer, CNA, Plomin, R, Rautanen, A, Sawcer, SJ, Trembath, RC, Viswanathan, AC, Wood, NW, Spencer, CCA, Band, G, Bellenguez, C, Freeman, C, Hellenthal, G, Giannoulatou, E, Pirinen, M, Pearson, R, Strange, A, Su, Z, Vukcevic, D, Langford, C, Hunt, SE, Edkins, S, Gwilliam, R, Blackburn, H, Bumpstead, SJ, Dronov, S, Gillman, M, Gray, E, Hammond, N, Jayakumar, A, Mccann, OT, Liddle, J, Potter, SC, Ravindrarajah, R, Ricketts, M, Waller, M, Weston, P, Widaa, S, Whittaker, P, Mccloskey, E, Eisman, J, Jones, G, Nicholson, G, Eastell, R, Sambrook, P, Prince, R, Dennison, E, Reid, I, Wark, J, Stebbings, S, Harrison, AA, Evans, DM, Duncan, EL & Wordsworth, BP 2016, 'The genetic associations of acute anterior uveitis and their overlap with the genetics of ankylosing spondylitis', Genes and Immunity, vol. 17, no. 1, pp. 46-51. https://doi.org/10.1038/gene.2015.49

TY - JOUR

T1 - The genetic associations of acute anterior uveitis and their overlap with the genetics of ankylosing spondylitis

AU - Robinson, P.C.

AU - Leo, P.J.

AU - Pointon, J.J.

AU - Harris, J.

AU - Cremin, K.

AU - Bradbury, L.A.

AU - Donnelly, P.

AU - Barroso, I.

AU - Blackwell, J.M.

AU - Bramon, E.

AU - Brown, M.A.

AU - Casas, J.P.

AU - Corvin, A.

AU - Deloukas, P.

AU - Duncanson, A.

AU - Jankowski, J.

AU - Markus, H.S.

AU - Mathew, C.G.

AU - Palmer, C.N.A.

AU - Plomin, R.

AU - Rautanen, A.

AU - Sawcer, S.J.

AU - Trembath, R.C.

AU - Viswanathan, A.C.

AU - Wood, N.W.

AU - Spencer, C.C.A.

AU - Band, G.

AU - Bellenguez, C.

AU - Freeman, C.

AU - Hellenthal, G.

AU - Giannoulatou, E.

AU - Pirinen, M.

AU - Pearson, R.

AU - Strange, A.

AU - Su, Z.

AU - Vukcevic, D.

AU - Langford, C.

AU - Hunt, S.E.

AU - Edkins, S.

AU - Gwilliam, R.

AU - Blackburn, H.

AU - Bumpstead, S.J.

AU - Dronov, S.

AU - Gillman, M.

AU - Gray, E.

AU - Hammond, N.

AU - Jayakumar, A.

AU - Mccann, O.T.

AU - Liddle, J.

AU - Potter, S.C.

AU - Ravindrarajah, R.

AU - Ricketts, M.

AU - Waller, M.

AU - Weston, P.

AU - Widaa, S.

AU - Whittaker, P.

AU - Mccloskey, E.

AU - Eisman, J.

AU - Jones, G.

AU - Nicholson, G.

AU - Eastell, R.

AU - Sambrook, P.

AU - Prince, Richard

AU - Dennison, E.

AU - Reid, I.

AU - Wark, J.

AU - Stebbings, S.

AU - Harrison, A.A.

AU - Evans, D.M.

AU - Duncan, E.L.

AU - Wordsworth, B.P.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - © 2016 Macmillan Publishers Limited All rights reserved. Acute anterior uveitis (AAU) involves inflammation of the iris and ciliary body of the eye. It occurs both in isolation and as a complication of ankylosing spondylitis (AS). It is strongly associated with HLA-B∗27, but previous studies have suggested that further genetic factors may confer additional risk. We sought to investigate this using the Illumina Exomechip microarray, to compare 1504 cases with AS and AAU, 1805 with AS but no AAU and 21 133 healthy controls. We also used a heterogeneity test to test the differences in effect size between AS with AAU and AS without AAU. In the analysis comparing AS+AAU+ cases versus controls, HLA-B∗27 and HLA-A∗02:01 were significantly associated with the presence of AAU (P

AB - © 2016 Macmillan Publishers Limited All rights reserved. Acute anterior uveitis (AAU) involves inflammation of the iris and ciliary body of the eye. It occurs both in isolation and as a complication of ankylosing spondylitis (AS). It is strongly associated with HLA-B∗27, but previous studies have suggested that further genetic factors may confer additional risk. We sought to investigate this using the Illumina Exomechip microarray, to compare 1504 cases with AS and AAU, 1805 with AS but no AAU and 21 133 healthy controls. We also used a heterogeneity test to test the differences in effect size between AS with AAU and AS without AAU. In the analysis comparing AS+AAU+ cases versus controls, HLA-B∗27 and HLA-A∗02:01 were significantly associated with the presence of AAU (P

U2 - 10.1038/gene.2015.49

DO - 10.1038/gene.2015.49

M3 - Article

C2 - 26610302

SN - 1466-4879

VL - 17

SP - 46

EP - 51

JO - Genes and Immunity

JF - Genes and Immunity

IS - 1

ER -

The genetic associations of acute anterior uveitis and their overlap with the genetics of ankylosing spondylitis

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