The genesis of new proteins and new biosyntheses

Benjamin Pouvreau

Research output: ThesisDoctoral Thesis

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Abstract

SFTl-1 (Sunflower Trypsin Inhibitor 1) was the first protein to be shown to have evolved de novo by genetic expansion within an existing protein. I term this type of de novo protein evolution "neoproteinisation". SFTl-1 emerges from a dual-product protein precursor, PawS1 (Preproalbumin with SFTl-1 ), by proteolytic cleavage to produce the two distinct mature proteins, albumin and SFTl-1. Here, I demonstrate SFTl-1 can emerge from other locations within PawS1 or other proteins. Then, I reveal another family of similarly buried peptides, widespread in flowering plants. This second example suggests neoproteinisation might be an overlooked mechanism for de novo protein evolution.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Mylne, Josh, Supervisor
  • Millar, Harvey, Supervisor
Award date16 Jan 2017
Publication statusUnpublished - 2016

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