The Future of Mesothelioma Research: Basic Science Research

Research output: Chapter in Book/Conference paperChapterpeer-review

Abstract

Our current understanding of mesothelioma in terms of disease induction, de-velopment, and treatment, is underpinned by decades of basic laboratory science. In this chapter, we discuss the tools that have been developed to aid our under-standing of mesothelioma such as cell lines and animal models. We then go on to detail the current use and understanding of conventional therapies for mesotheli-oma e.g. chemotherapy, surgery and radiotherapy; plus their mechanisms of ac-tion, and why they may be ineffective. Finally, we discuss a range of newer treatments that are either undergoing clinical trials or are still in the earlier stages of preclinical investigation. These including a growing number of immunothera-pies (e.g. checkpoint inhibitors), plus targeted therapies, the search for clinical bi-omarkers to predict whether patients with mesothelioma might respond to particu-lar treatments, and combined therapies where conventional treatments may be added to newer drugs. The strategy of repositioning existing drugs, approved for other diseases, to treat mesothelioma is also discussed.
Original languageEnglish
Title of host publicationCaring for Patients with Mesothelioma: Principles and Guidelines
Place of PublicationSwitzerland
PublisherSpringer Nature
Chapter18
Pages203-227
Number of pages24
ISBN (Electronic)978-3-319-96244-3
ISBN (Print)978-3-319-96243-6
DOIs
Publication statusPublished - 2019

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