The function of the human diaphragm as a volume pump and measurement of its efficiency

Bhajan Singh

The function of the human diaphragm as a volume pump and measurement of its efficiency

Bhajan Singh

Graduate Research School

Research output: Thesis › Doctoral Thesis

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Abstract

[Truncated abstract] The function of the diaphragm as a volume pump has not been adequately evaluated because there are no accurate methods to measure the volume displaced by diaphragm motion (ΔVdi). As a consequence, the work done, power output and efficiency of the diaphragm have not been measured. Efficiency of the diaphragm could be measured by relating the power output of the diaphragm to its neural activation. The aims of this thesis were to (a) develop a new biplanar radiographic method to measure ΔVdi and use this to evaluate the effect of costophrenic fibrosis and emphysema on ΔVdi, (b) develop a new fluoroscopic method to enable breath-by-breath measurements of ΔVdi, (c) evaluate a method for quantifying neural activation of the diaphragm, and (d) combine measurements of transdiaphragmatic pressure, ΔVdi, inspiratory duration and neural activation of the diaphragm to quantify the neuromechanical efficiency of the diaphragm

Original language	English
Qualification	Doctor of Philosophy
Publication status	Unpublished - 2003

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Singh, B. (2003). The function of the human diaphragm as a volume pump and measurement of its efficiency.

@phdthesis{253e686f281b4535a1cfc7e3bf9a40d9,

title = "The function of the human diaphragm as a volume pump and measurement of its efficiency",

abstract = "[Truncated abstract] The function of the diaphragm as a volume pump has not been adequately evaluated because there are no accurate methods to measure the volume displaced by diaphragm motion (ΔVdi). As a consequence, the work done, power output and efficiency of the diaphragm have not been measured. Efficiency of the diaphragm could be measured by relating the power output of the diaphragm to its neural activation. The aims of this thesis were to (a) develop a new biplanar radiographic method to measure ΔVdi and use this to evaluate the effect of costophrenic fibrosis and emphysema on ΔVdi, (b) develop a new fluoroscopic method to enable breath-by-breath measurements of ΔVdi, (c) evaluate a method for quantifying neural activation of the diaphragm, and (d) combine measurements of transdiaphragmatic pressure, ΔVdi, inspiratory duration and neural activation of the diaphragm to quantify the neuromechanical efficiency of the diaphragm",

keywords = "Diaphragm, Mechanical properties, Physiology, Diaphragm power input, Diaphragm electromyogram, Diaphragm fluoroscopy, Pulmonary hyperinflation, Asbestos pleural disease, Emphysema",

author = "Bhajan Singh",

year = "2003",

language = "English",

}

TY - THES

T1 - The function of the human diaphragm as a volume pump and measurement of its efficiency

AU - Singh, Bhajan

PY - 2003

Y1 - 2003

N2 - [Truncated abstract] The function of the diaphragm as a volume pump has not been adequately evaluated because there are no accurate methods to measure the volume displaced by diaphragm motion (ΔVdi). As a consequence, the work done, power output and efficiency of the diaphragm have not been measured. Efficiency of the diaphragm could be measured by relating the power output of the diaphragm to its neural activation. The aims of this thesis were to (a) develop a new biplanar radiographic method to measure ΔVdi and use this to evaluate the effect of costophrenic fibrosis and emphysema on ΔVdi, (b) develop a new fluoroscopic method to enable breath-by-breath measurements of ΔVdi, (c) evaluate a method for quantifying neural activation of the diaphragm, and (d) combine measurements of transdiaphragmatic pressure, ΔVdi, inspiratory duration and neural activation of the diaphragm to quantify the neuromechanical efficiency of the diaphragm

AB - [Truncated abstract] The function of the diaphragm as a volume pump has not been adequately evaluated because there are no accurate methods to measure the volume displaced by diaphragm motion (ΔVdi). As a consequence, the work done, power output and efficiency of the diaphragm have not been measured. Efficiency of the diaphragm could be measured by relating the power output of the diaphragm to its neural activation. The aims of this thesis were to (a) develop a new biplanar radiographic method to measure ΔVdi and use this to evaluate the effect of costophrenic fibrosis and emphysema on ΔVdi, (b) develop a new fluoroscopic method to enable breath-by-breath measurements of ΔVdi, (c) evaluate a method for quantifying neural activation of the diaphragm, and (d) combine measurements of transdiaphragmatic pressure, ΔVdi, inspiratory duration and neural activation of the diaphragm to quantify the neuromechanical efficiency of the diaphragm

KW - Diaphragm

KW - Mechanical properties

KW - Physiology

KW - Diaphragm power input

KW - Diaphragm electromyogram

KW - Diaphragm fluoroscopy

KW - Pulmonary hyperinflation

KW - Asbestos pleural disease

KW - Emphysema

M3 - Doctoral Thesis

ER -

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