The Final Player in the Coenzyme A Biosynthetic Pathway

Nicholas O'Toole, M. Cygler

Research output: Contribution to journalReview article

1 Citation (Scopus)


The determination of the crystal structure of human phosphopantothenoylcysteine synthetase completes our knowledge of the enzyme structures involved in all steps of coenzyme A biosynthesis. This structure provides insight into the differences between bacterial and mammalian forms of the enzyme and may guide the structure-based development of novel antibacterial compounds.
Original languageEnglish
Pages (from-to)899-900
Publication statusPublished - 2003


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