The extracellular microscape governs mesenchymal stem cell fate

William J. Hadden, Yu Suk Choi

    Research output: Contribution to journalReview articlepeer-review

    14 Citations (Scopus)


    Each cell forever interacts with its extracellular matrix (ECM); a stem cell relies on this interaction to guide differentiation. The stiffness, nanotopography, protein composition, stress and strain inherent to any given ECM influences stem cell lineage commitment. This interaction is dynamic, multidimensional and reciprocally evolving through time, and from this concerted exchange the macroscopic tissues that comprise living organisms are formed. Mesenchymal stem cells can give rise to bone, cartilage, tendon and muscle thus attempts to manipulate their differentiation must heed the physical properties of incredibly complex native microenvironments to realize regenerative goals.

    Original languageEnglish
    Article number16
    JournalJournal of Biological Engineering
    Issue number1
    Publication statusPublished - 21 Nov 2016


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