The expression of α(1)-acid glycoprotein mRNA during rat development. High levels of expression in the decidua

T. Thomas, S. Fletcher, G. C T Yeoh, G. Schreiber

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

During the acute phase response to inflammation the plasma concentration of some proteins, such as α(1)-acid glycoprotein (AGP), increases dramatically. Since breakdown and remodeling of tissue is common to both nidation and inflammation we studied the tissue distribution and regulation of AGP mRNA levels during the embryonic development of the rat. High levels of mRNA coding for AGP were detected in the placenta during early fetal development. Expression of this mRNA was confined to the decidua and was first observed approximately 1 day after implantation when proliferation of the decidua is already well advanced. Maximum levels were attained about 5 days after implantation, after which the levels decreased rapidly. In contast to the high levels of AGP mRNA in the decidua only very low levels were detected in fetal liver and visceral yolk sac, and there was only a small increase in the levels in maternal liver. Corticosteroid hormone responsiveness of AGP mRNA synthesis by hepatocytes appeared 3 days before birth. It is likely that the synthesis of AGP by the cells of the decidua is important in establishing the precisely controlled interaction between mother and embryo during nidation.

Original languageEnglish
Pages (from-to)5784-5790
Number of pages7
JournalJournal of Biological Chemistry
Volume264
Issue number10
Publication statusPublished - 1 Jan 1989
Externally publishedYes

Fingerprint

Decidua
Rats
Glycoproteins
Messenger RNA
Acids
Liver
Tissue
Inflammation
Yolk Sac
Acute-Phase Reaction
Tissue Distribution
Fetal Development
Placenta
Embryonic Development
Hepatocytes
Adrenal Cortex Hormones
Embryonic Structures
Mothers
Parturition
Hormones

Cite this

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The expression of α(1)-acid glycoprotein mRNA during rat development. High levels of expression in the decidua. / Thomas, T.; Fletcher, S.; Yeoh, G. C T; Schreiber, G.

In: Journal of Biological Chemistry, Vol. 264, No. 10, 01.01.1989, p. 5784-5790.

Research output: Contribution to journalArticle

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