The expanding roles of long non-coding RNAs in the regulation of cancer stem cells

Zhaowu Ma, Ying-Ying Wang, Hong-Wu Xin, Lingzhi Wang, Frank Arfuso, Arunasalam Dharmarajan, Alan Kumar, Hong Wang, Feng-Ru Tang, Sudha Warrier, Vinay Tergaonkar

Research output: Contribution to journalArticlepeer-review

76 Citations (Scopus)


Long non-coding RNAs (lncRNAs) are a novel class of gene regulators playing multifaceted roles in physiological processes as well as pathological conditions such as cancer. Cancer stem cells (CSCs) are a small subset of tumor cells that constitute the origin and development of various malignant tumors. CSCs have been identified in a wide spectrum of human tumors and could act as a critical link underlying the processes of tumor metastasis and recurrence. Mounting evidence indicates that lncRNAs are aberrantly expressed in diverse CSCs and regulate CSC properties at different molecular levels. Here, we very briefly summarize the recent findings on the potential roles of lncRNAs in regulating various functions of CSCs, and elaborate on how can lncRNAs impact CSC properties via interacting with other macromolecules at the epigenetic, transcriptional, and post-transcriptional levels. This mini-review also highlights the understanding of the modular regulatory principles of lncRNA interactions in CSCs.
Original languageEnglish
Pages (from-to)17-20
Number of pages4
JournalInternational Journal of Biochemistry and Cell Biology
Publication statusPublished - Mar 2019
Externally publishedYes


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