The evaluation of the long-term motor outcome of children and youth with Cerebral Palsy treated with Botulinum toxin type A within a comprehensive spasticity management service

Jane Valentine

doi:10.26182/5e97c8362367b

The evaluation of the long-term motor outcome of children and youth with Cerebral Palsy treated with Botulinum toxin type A within a comprehensive spasticity management service

Jane Valentine

UWA Medical School

Research output: Thesis › Doctoral Thesis

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Abstract

This thesis expands the evidence base for the long-term outcomes of children and adolescents with Cerebral Palsy (CP) treated with Botulinum toxin (BoNTA). A cohort of children with CP in WA who have been managed with BoNTA since 1995 were studied and our results confirm long-term use of BoNTA is associated with gross motor stability when used within evidence-based guidelines and in a model of goal-based decision making by a multidisciplinary team. It is important to consider dose and frequency to ensure muscle recovery from the neurogenic atrophy effects of BoNTA and ensure muscle strength is maximised post BoNTA use.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Elliott, Catherine, Supervisor Blair, Eve, Supervisor Forbes, David, Supervisor
Award date	2 Jan 2020
DOIs	https://doi.org/10.26182/5e97c8362367b
Publication status	Unpublished - 2020

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10.26182/5e97c8362367b

TH20 36 THESIS - DOCTOR OF PHILOSOPHY - VALENTINE Jane Patricia - 2020
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Cite this

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title = "The evaluation of the long-term motor outcome of children and youth with Cerebral Palsy treated with Botulinum toxin type A within a comprehensive spasticity management service",

abstract = "This thesis expands the evidence base for the long-term outcomes of children and adolescents with Cerebral Palsy (CP) treated with Botulinum toxin (BoNTA). A cohort of children with CP in WA who have been managed with BoNTA since 1995 were studied and our results confirm long-term use of BoNTA is associated with gross motor stability when used within evidence-based guidelines and in a model of goal-based decision making by a multidisciplinary team. It is important to consider dose and frequency to ensure muscle recovery from the neurogenic atrophy effects of BoNTA and ensure muscle strength is maximised post BoNTA use. ",

keywords = "Cerebral palsy, Muscle morphology, Botulinum toxin, long term outcome, childhood",

author = "Jane Valentine",

year = "2020",

doi = "10.26182/5e97c8362367b",

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school = "The University of Western Australia",

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N2 - This thesis expands the evidence base for the long-term outcomes of children and adolescents with Cerebral Palsy (CP) treated with Botulinum toxin (BoNTA). A cohort of children with CP in WA who have been managed with BoNTA since 1995 were studied and our results confirm long-term use of BoNTA is associated with gross motor stability when used within evidence-based guidelines and in a model of goal-based decision making by a multidisciplinary team. It is important to consider dose and frequency to ensure muscle recovery from the neurogenic atrophy effects of BoNTA and ensure muscle strength is maximised post BoNTA use.

AB - This thesis expands the evidence base for the long-term outcomes of children and adolescents with Cerebral Palsy (CP) treated with Botulinum toxin (BoNTA). A cohort of children with CP in WA who have been managed with BoNTA since 1995 were studied and our results confirm long-term use of BoNTA is associated with gross motor stability when used within evidence-based guidelines and in a model of goal-based decision making by a multidisciplinary team. It is important to consider dose and frequency to ensure muscle recovery from the neurogenic atrophy effects of BoNTA and ensure muscle strength is maximised post BoNTA use.

KW - Cerebral palsy

KW - Muscle morphology

KW - Botulinum toxin

KW - long term outcome

KW - childhood

U2 - 10.26182/5e97c8362367b

DO - 10.26182/5e97c8362367b

M3 - Doctoral Thesis

ER -

The evaluation of the long-term motor outcome of children and youth with Cerebral Palsy treated with Botulinum toxin type A within a comprehensive spasticity management service

Abstract

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