The era of genome-wide association studies: opportunities and challenges for asthma genetics

G. Zhang, Jack Goldblatt, Peter Le Souef

    Research output: Contribution to journalArticle

    16 Citations (Scopus)

    Abstract

    In the era of genome-wide association (GWA) studies, delineating pathogenic asthma genetic pathways has provided bothchallenges and opportunities. Initial GWA studies on asthma and asthma-like phenotypes provided some successes in termsof ascertaining new potential asthma candidate genes. However, due to asthma having a heterogeneous etiology, replicationsof these genotype–phenotype association studies are generally lacking. Furthermore, genes by environment interactionsare generally not considered when GWA studies are conducted. Therefore, there is a need for extensive collaborations inmulti-disciplinary research fields, including different environments and populations, to investigate the functional importanceof variations in the human genome in relation to asthma pathogenesis.
    Original languageEnglish
    Pages (from-to)624-628
    JournalJournal of Human Genetics
    Volume54
    Issue number11
    DOIs
    Publication statusPublished - 2009

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