Abstract
In the era of genome-wide association (GWA) studies, delineating pathogenic asthma genetic pathways has provided bothchallenges and opportunities. Initial GWA studies on asthma and asthma-like phenotypes provided some successes in termsof ascertaining new potential asthma candidate genes. However, due to asthma having a heterogeneous etiology, replicationsof these genotype–phenotype association studies are generally lacking. Furthermore, genes by environment interactionsare generally not considered when GWA studies are conducted. Therefore, there is a need for extensive collaborations inmulti-disciplinary research fields, including different environments and populations, to investigate the functional importanceof variations in the human genome in relation to asthma pathogenesis.
Original language | English |
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Pages (from-to) | 624-628 |
Journal | Journal of Human Genetics |
Volume | 54 |
Issue number | 11 |
DOIs | |
Publication status | Published - 2009 |