The epidemiology of atypical mycobacterial diseases in northern England : A space-time clustering and Generalized Linear Modelling approach

S.P. Rushton, M. Goodfellow, A.G. O'Donnell, J.G. Magee

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    The incidence of infection by mycobacteria, other than tubercle bacilli (MOTT) is increasing in the United Kingdom, Europe and the United States. These diseases increase morbidity and are an increasing public health concern. However, the epidemiology of disease due to these species is not well characterized. We used space-time clustering approaches and Generalized Linear Modelling to investigate the potential predictors of disease in cases of infection by organisms of the Mycobacterium avium complex (MAC) and M. malmoense recorded in the north of England during 2000-2005. There was significant spatial and temporal clustering in juvenile cases of infection by MAC but not for cases of infection in adults by either species. There were no significant predictors of infection by M. malmoense or juvenile cases of M. avium. Incidence of disease caused by M. avium in adults was significantly related to health deprivation and weakly related to rainfall. We consider possible reasons for the difference in epidemiology in infection by M. avium in adults and juveniles.
    Original languageEnglish
    Pages (from-to)765-774
    JournalEpidemiology and Infection
    Volume135
    Issue number5
    DOIs
    Publication statusPublished - 2007

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