Abstract
Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disorder linked to obesity and the metabolic syndrome. NAFLD is associated with increased risk of type II diabetes mellitus, atherosclerotic cardiovascular disease, cirrhosis and hepatocellular cancer. This thesis describes developmental origins and risk factors for NAFLD in adolescents in the general population. Unique findings included (1) heritability of risk factors for NAFLD, (2) parental pre-pregnancy and pregnancy-related health and sociodemographic factors, (3) factors through the life course, including infant nutrition and subsequent dietary patterns, trajectories of adiposity gain, obesity, metabolic syndrome, polycystic ovary syndrome and adipokine abnormalities associated with adolescent NAFLD.
Original language | English |
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Qualification | Doctor of Philosophy |
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Award date | 14 May 2018 |
DOIs | |
Publication status | Unpublished - 2018 |