The epidemiology and significance of nonalcoholic fatty liver disease in adolescents

Research output: ThesisDoctoral Thesis

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Abstract

Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disorder linked to obesity and the metabolic syndrome. NAFLD is associated with increased risk of type II diabetes mellitus, atherosclerotic cardiovascular disease, cirrhosis and hepatocellular cancer. This thesis describes developmental origins and risk factors for NAFLD in adolescents in the general population. Unique findings included (1) heritability of risk factors for NAFLD, (2) parental pre-pregnancy and pregnancy-related health and socio­demographic factors, (3) factors through the life course, including infant nutrition and subsequent dietary patterns, trajectories of adiposity gain, obesity, metabolic syndrome, polycystic ovary syndrome and adipokine abnormalities associated with adolescent NAFLD.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Olynyk, John, Supervisor
  • Adams, Leon, Supervisor
  • Beilin, Lawrence, Supervisor
  • De Klerk, Nicholas, Supervisor
Award date14 May 2018
DOIs
Publication statusUnpublished - 2018

Fingerprint

Epidemiology
Obesity
Pregnancy
Adipokines
Polycystic Ovary Syndrome
Adiposity
Liver Neoplasms
Type 2 Diabetes Mellitus
Fibrosis
Cardiovascular Diseases
Non-alcoholic Fatty Liver Disease
Liver
Health
Population

Cite this

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title = "The epidemiology and significance of nonalcoholic fatty liver disease in adolescents",
abstract = "Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disorder linked to obesity and the metabolic syndrome. NAFLD is associated with increased risk of type II diabetes mellitus, atherosclerotic cardiovascular disease, cirrhosis and hepatocellular cancer. This thesis describes developmental origins and risk factors for NAFLD in adolescents in the general population. Unique findings included (1) heritability of risk factors for NAFLD, (2) parental pre-pregnancy and pregnancy-related health and socio­demographic factors, (3) factors through the life course, including infant nutrition and subsequent dietary patterns, trajectories of adiposity gain, obesity, metabolic syndrome, polycystic ovary syndrome and adipokine abnormalities associated with adolescent NAFLD.",
keywords = "Fatty liver, Nonalcoholic fatty liver, Metabolic syndrome, Raine Study, Obesity, Epidemiology, Adolescents",
author = "Ayonrinde, {Oyekoya Taiwo}",
year = "2018",
doi = "10.4225/23/5b35a837b3980",
language = "English",
school = "The University of Western Australia",

}

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AU - Ayonrinde, Oyekoya Taiwo

PY - 2018

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N2 - Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disorder linked to obesity and the metabolic syndrome. NAFLD is associated with increased risk of type II diabetes mellitus, atherosclerotic cardiovascular disease, cirrhosis and hepatocellular cancer. This thesis describes developmental origins and risk factors for NAFLD in adolescents in the general population. Unique findings included (1) heritability of risk factors for NAFLD, (2) parental pre-pregnancy and pregnancy-related health and socio­demographic factors, (3) factors through the life course, including infant nutrition and subsequent dietary patterns, trajectories of adiposity gain, obesity, metabolic syndrome, polycystic ovary syndrome and adipokine abnormalities associated with adolescent NAFLD.

AB - Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disorder linked to obesity and the metabolic syndrome. NAFLD is associated with increased risk of type II diabetes mellitus, atherosclerotic cardiovascular disease, cirrhosis and hepatocellular cancer. This thesis describes developmental origins and risk factors for NAFLD in adolescents in the general population. Unique findings included (1) heritability of risk factors for NAFLD, (2) parental pre-pregnancy and pregnancy-related health and socio­demographic factors, (3) factors through the life course, including infant nutrition and subsequent dietary patterns, trajectories of adiposity gain, obesity, metabolic syndrome, polycystic ovary syndrome and adipokine abnormalities associated with adolescent NAFLD.

KW - Fatty liver

KW - Nonalcoholic fatty liver

KW - Metabolic syndrome

KW - Raine Study

KW - Obesity

KW - Epidemiology

KW - Adolescents

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DO - 10.4225/23/5b35a837b3980

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