The emerging roles of hnRNPK

Ziyi Wang, Heng Qiu, Jianbo He, Langxia Liu, Wei Xue, Archa Fox, Jennifer Tickner, Jiake Xu

Research output: Contribution to journalReview article

Abstract

Heterogeneous nuclear ribonucleoprotein K (hnRNPK) is an DNA/RNA-binding protein and regulates a wide range of biological processes and disease pathogenesis. It contains 3 K-homologous (KH) domains, which are conserved in other RNA-binding proteins, mediate nucleic acid binding activity, and function as an enhancer or repressor of gene transcription. Phosphorylation of the protein alters its regulatory function, which also enables the protein to serve as a docking platform for the signal transduction proteins. In terms of the function of hnRNPK, it is central to many cellular events, including long noncoding RNA (lncRNA) regulation, cancer development and bone homoeostasis. Many studies have identified hnRNPK as an oncogene, where it is overexpressed in cancer tissues compared with the nonneoplastic tissues and its expression level is related to the prognosis of different types of host malignancies. However, hnRNPK has also been identified as a tumour suppressor, as it is important for the activation of the p53/p21 pathway. Recently, the protein is also found to be exclusively related to the regulation of paraspeckles and lncRNAs such as Neat1, Lncenc1 and Xist. Interestingly, hnRNPK has been found to associate with the Kabuki-like syndrome and Au-Kline syndrome with prominent skeletal abnormalities. In vitro study revealed that the hnRNPK protein is essential for the formation of osteoclast, in line with its importance in the skeletal system.

Original languageEnglish
JournalJournal of Cellular Physiology
DOIs
Publication statusE-pub ahead of print - 19 Sep 2019

Fingerprint

Heterogeneous-Nuclear Ribonucleoprotein K
Long Noncoding RNA
RNA-Binding Proteins
Proteins
Biological Phenomena
Bone Neoplasms
Neoplasms
Signal transduction
Phosphorylation
DNA-Binding Proteins
Osteoclasts
Transcription
Oncogenes
Nucleic Acids
Tumors
Signal Transduction
Bone
Homeostasis
Genes
Chemical activation

Cite this

@article{771ad8da47364a68a29b83b0c3d904c4,
title = "The emerging roles of hnRNPK",
abstract = "Heterogeneous nuclear ribonucleoprotein K (hnRNPK) is an DNA/RNA-binding protein and regulates a wide range of biological processes and disease pathogenesis. It contains 3 K-homologous (KH) domains, which are conserved in other RNA-binding proteins, mediate nucleic acid binding activity, and function as an enhancer or repressor of gene transcription. Phosphorylation of the protein alters its regulatory function, which also enables the protein to serve as a docking platform for the signal transduction proteins. In terms of the function of hnRNPK, it is central to many cellular events, including long noncoding RNA (lncRNA) regulation, cancer development and bone homoeostasis. Many studies have identified hnRNPK as an oncogene, where it is overexpressed in cancer tissues compared with the nonneoplastic tissues and its expression level is related to the prognosis of different types of host malignancies. However, hnRNPK has also been identified as a tumour suppressor, as it is important for the activation of the p53/p21 pathway. Recently, the protein is also found to be exclusively related to the regulation of paraspeckles and lncRNAs such as Neat1, Lncenc1 and Xist. Interestingly, hnRNPK has been found to associate with the Kabuki-like syndrome and Au-Kline syndrome with prominent skeletal abnormalities. In vitro study revealed that the hnRNPK protein is essential for the formation of osteoclast, in line with its importance in the skeletal system.",
keywords = "cancer, cell signal transduction, gene expression regulation, hnRNPK, lncRNA, skeletal remodelling",
author = "Ziyi Wang and Heng Qiu and Jianbo He and Langxia Liu and Wei Xue and Archa Fox and Jennifer Tickner and Jiake Xu",
year = "2019",
month = "9",
day = "19",
doi = "10.1002/jcp.29186",
language = "English",
journal = "Journal Cellular Physiology",
issn = "0021-9541",
publisher = "John Wiley & Sons",

}

The emerging roles of hnRNPK. / Wang, Ziyi; Qiu, Heng; He, Jianbo; Liu, Langxia; Xue, Wei; Fox, Archa; Tickner, Jennifer; Xu, Jiake.

In: Journal of Cellular Physiology, 19.09.2019.

Research output: Contribution to journalReview article

TY - JOUR

T1 - The emerging roles of hnRNPK

AU - Wang, Ziyi

AU - Qiu, Heng

AU - He, Jianbo

AU - Liu, Langxia

AU - Xue, Wei

AU - Fox, Archa

AU - Tickner, Jennifer

AU - Xu, Jiake

PY - 2019/9/19

Y1 - 2019/9/19

N2 - Heterogeneous nuclear ribonucleoprotein K (hnRNPK) is an DNA/RNA-binding protein and regulates a wide range of biological processes and disease pathogenesis. It contains 3 K-homologous (KH) domains, which are conserved in other RNA-binding proteins, mediate nucleic acid binding activity, and function as an enhancer or repressor of gene transcription. Phosphorylation of the protein alters its regulatory function, which also enables the protein to serve as a docking platform for the signal transduction proteins. In terms of the function of hnRNPK, it is central to many cellular events, including long noncoding RNA (lncRNA) regulation, cancer development and bone homoeostasis. Many studies have identified hnRNPK as an oncogene, where it is overexpressed in cancer tissues compared with the nonneoplastic tissues and its expression level is related to the prognosis of different types of host malignancies. However, hnRNPK has also been identified as a tumour suppressor, as it is important for the activation of the p53/p21 pathway. Recently, the protein is also found to be exclusively related to the regulation of paraspeckles and lncRNAs such as Neat1, Lncenc1 and Xist. Interestingly, hnRNPK has been found to associate with the Kabuki-like syndrome and Au-Kline syndrome with prominent skeletal abnormalities. In vitro study revealed that the hnRNPK protein is essential for the formation of osteoclast, in line with its importance in the skeletal system.

AB - Heterogeneous nuclear ribonucleoprotein K (hnRNPK) is an DNA/RNA-binding protein and regulates a wide range of biological processes and disease pathogenesis. It contains 3 K-homologous (KH) domains, which are conserved in other RNA-binding proteins, mediate nucleic acid binding activity, and function as an enhancer or repressor of gene transcription. Phosphorylation of the protein alters its regulatory function, which also enables the protein to serve as a docking platform for the signal transduction proteins. In terms of the function of hnRNPK, it is central to many cellular events, including long noncoding RNA (lncRNA) regulation, cancer development and bone homoeostasis. Many studies have identified hnRNPK as an oncogene, where it is overexpressed in cancer tissues compared with the nonneoplastic tissues and its expression level is related to the prognosis of different types of host malignancies. However, hnRNPK has also been identified as a tumour suppressor, as it is important for the activation of the p53/p21 pathway. Recently, the protein is also found to be exclusively related to the regulation of paraspeckles and lncRNAs such as Neat1, Lncenc1 and Xist. Interestingly, hnRNPK has been found to associate with the Kabuki-like syndrome and Au-Kline syndrome with prominent skeletal abnormalities. In vitro study revealed that the hnRNPK protein is essential for the formation of osteoclast, in line with its importance in the skeletal system.

KW - cancer

KW - cell signal transduction

KW - gene expression regulation

KW - hnRNPK

KW - lncRNA

KW - skeletal remodelling

UR - http://www.scopus.com/inward/record.url?scp=85073978307&partnerID=8YFLogxK

U2 - 10.1002/jcp.29186

DO - 10.1002/jcp.29186

M3 - Review article

JO - Journal Cellular Physiology

JF - Journal Cellular Physiology

SN - 0021-9541

ER -