[Truncated abstract] This project was developed back in 2006 with the aim to detect loci or gene(s) that may influence susceptibility to Type 2 Diabetes (T2D) and related traits in individuals of Arab descent. This was required the comparative study of patients and unaffected individuals. Samples were made available from consenting volunteers from United Arab Emirates (UAE) population. Phenotypic data and the genotyping results were systematically compiled in biobanking and data repository known as the "Emirates Family Registry" (EFR). When the project was initially conceived, data on DNA haplotypes in the tribes of the Middle-East was limited. Coincidentally, significant advances in DNA technology, particularly in the field of DNA arrays, provide the opportunity to study this group of people. Over the past four years, basic infrastructure that will allow longitudinal genetic studies have started to emerge. This study has specifically benefited through access to information on the Bedouin people, a predominantly desert-dwelling Arab ethnic group. In the first instance, the study examined the evolutionary relationship between the Arab Bedouin and other ethnic groups. Polymorphic Alu insertions (POALINS) are genetic markers that are widely distributed through the human genome. These markers have been used in a range of applications, including anthropological analyses of human populations.
|Qualification||Doctor of Philosophy|
|Publication status||Unpublished - 2011|