The Effects of Tamoxifen on Plasma Lipoprotein(a) Concentrations: Systematic Review and Meta-Analysis

Amirhossein Sahebkar, Maria Corina Serban, Peter Penson, Camelia Gurban, Sorin Ursoniu, Peter P. Toth, Steven R. Jones, Giuseppe Lippi, Kazuhiko Kotani, Karam Kostner, Manfredi Rizzo, Jacek Rysz, Maciej Banach, For The Lipid And Blood Pressure Meta-Analysis Collaboration (Lbpmc) Group

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Introduction: Tamoxifen is a selective estrogen receptor modulator widely used in the treatment of breast cancer. Tamoxifen therapy is associated with lower circulating low-density lipoprotein cholesterol and increased triglycerides, but its effects on other lipids are less well studied. Aims: We aimed to investigate the effect of tamoxifen on circulating concentrations of lipoprotein(a) [Lp(a)] through a meta-analysis of available randomized controlled trials (RCTs) and observational studies. Methods: This study was registered in the PROSPERO database (CRD42016036890). Scopus, MEDLINE and EMBASE were searched from inception until 22 March 2016 to identify studies investigating the effect of tamoxifen on Lp(a) values in humans. Meta-analysis was performed using an inverse variance-weighted, random-effects model with standardized mean difference (SMD) as the effect size estimate. Results: Meta-analysis of five studies with 215 participants suggested a statistically significant reduction of Lp(a) levels following tamoxifen treatment (SMD −0.41, 95% confidence interval −0.68 to −0.14, p = 0.003). This effect was robust in the sensitivity analysis. Conclusions: Meta-analysis suggested a statistically significant reduction of Lp(a) levels following tamoxifen treatment. Further well-designed trials are required to validate these results.

Original languageEnglish
Pages (from-to)1187-1197
Number of pages11
JournalDrugs
Volume77
Issue number11
DOIs
Publication statusPublished - 1 Jun 2017

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    Sahebkar, A., Serban, M. C., Penson, P., Gurban, C., Ursoniu, S., Toth, P. P., Jones, S. R., Lippi, G., Kotani, K., Kostner, K., Rizzo, M., Rysz, J., Banach, M., & For The Lipid And Blood Pressure Meta-Analysis Collaboration (Lbpmc) Group (2017). The Effects of Tamoxifen on Plasma Lipoprotein(a) Concentrations: Systematic Review and Meta-Analysis. Drugs, 77(11), 1187-1197. https://doi.org/10.1007/s40265-017-0767-4