The effects of repetitive transcranial magnetic stimulation in an animal model of tinnitus

Wilhelmina H. A. M. Mulders, Vanessa Vooys, Kalina Makowiecki, Alex D. Tang, Jennifer Rodger

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    Tinnitus (phantom auditory perception associated with hearing loss) can seriously affect wellbeing. Its neural substrate is unknown however it has been linked with abnormal activity in auditory pathways. Though no cure currently exists, repetitive transcranial magnetic stimulation (rTMS) has been shown to reduce tinnitus in some patients, possibly via induction of cortical plasticity involving brain derived neurotrophic factor (BDNF). We examined whether low intensity rTMS (LI-rTMS) alleviates signs of tinnitus in a Guinea pig model and whether this involves changes in BDNF expression and hyperactivity in inferior colliculus. Acoustic trauma was used to evoke hearing loss, central hyperactivity and tinnitus. When animals developed tinnitus, treatment commenced (10 sessions of 10 minutes 1 Hz LI-rTMS or sham over auditory cortex over 14 days). After treatment ceased animals were tested for tinnitus, underwent single-neuron recordings in inferior colliculus to assess hyperactivity and samples from cortex and inferior colliculus were taken for BDNF ELISA. Analysis revealed a significant reduction of tinnitus after LI-rTMS compared to sham, without a statistical significant effect on BDNF levels or hyperactivity. This suggests that LI-rTMS alleviates behavioural signs of tinnitus by a mechanism independent of inferior colliculus hyperactivity and BDNF levels and opens novel therapeutic avenues for tinnitus treatment.

    Original languageEnglish
    Article number38234
    JournalScientific Reports
    Volume6
    DOIs
    Publication statusPublished - 1 Dec 2016

    Fingerprint

    Tinnitus
    Transcranial Magnetic Stimulation
    Animal Models
    Brain-Derived Neurotrophic Factor
    Inferior Colliculi
    Central Hearing Loss
    Auditory Perception
    Noise-Induced Hearing Loss
    Auditory Pathways
    Auditory Cortex
    Therapeutics
    Hearing Loss
    Guinea Pigs
    Enzyme-Linked Immunosorbent Assay
    Neurons

    Cite this

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    abstract = "Tinnitus (phantom auditory perception associated with hearing loss) can seriously affect wellbeing. Its neural substrate is unknown however it has been linked with abnormal activity in auditory pathways. Though no cure currently exists, repetitive transcranial magnetic stimulation (rTMS) has been shown to reduce tinnitus in some patients, possibly via induction of cortical plasticity involving brain derived neurotrophic factor (BDNF). We examined whether low intensity rTMS (LI-rTMS) alleviates signs of tinnitus in a Guinea pig model and whether this involves changes in BDNF expression and hyperactivity in inferior colliculus. Acoustic trauma was used to evoke hearing loss, central hyperactivity and tinnitus. When animals developed tinnitus, treatment commenced (10 sessions of 10 minutes 1 Hz LI-rTMS or sham over auditory cortex over 14 days). After treatment ceased animals were tested for tinnitus, underwent single-neuron recordings in inferior colliculus to assess hyperactivity and samples from cortex and inferior colliculus were taken for BDNF ELISA. Analysis revealed a significant reduction of tinnitus after LI-rTMS compared to sham, without a statistical significant effect on BDNF levels or hyperactivity. This suggests that LI-rTMS alleviates behavioural signs of tinnitus by a mechanism independent of inferior colliculus hyperactivity and BDNF levels and opens novel therapeutic avenues for tinnitus treatment.",
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    The effects of repetitive transcranial magnetic stimulation in an animal model of tinnitus. / Mulders, Wilhelmina H. A. M.; Vooys, Vanessa; Makowiecki, Kalina; Tang, Alex D.; Rodger, Jennifer.

    In: Scientific Reports, Vol. 6, 38234, 01.12.2016.

    Research output: Contribution to journalArticle

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