TY - JOUR
T1 - The effects of progabide (SL 76002) on locomotor activity and conditioned place preference induced by d-Amphetamine
AU - Di Scala, Georges
AU - Martin-Iverson, Mathew T.
AU - Phillips, Anthony G.
AU - Fibiger, Hans C.
PY - 1985/1/2
Y1 - 1985/1/2
N2 - The effect of prior treatment with a GABA mimetic, SL 76002 (100 mg/kg i.p.), on amphetamine-induced locomotor activity and conditioned place preferences with amphetamine (1.5 mg/kg i.p.) was investigated. SL 76002 significantly attenuated the motor stimulant effects of amphetamine, without influencing the rewarding properties at least as determined by the place preference procedure. When injected alone, SL 76002 did not affect handling-induced locomotor activation, nor did it exhibit any aversive or reinforcing properties. The results suggest that separate neural systems may subserve the motor and rewarding properties of amphetamine.
AB - The effect of prior treatment with a GABA mimetic, SL 76002 (100 mg/kg i.p.), on amphetamine-induced locomotor activity and conditioned place preferences with amphetamine (1.5 mg/kg i.p.) was investigated. SL 76002 significantly attenuated the motor stimulant effects of amphetamine, without influencing the rewarding properties at least as determined by the place preference procedure. When injected alone, SL 76002 did not affect handling-induced locomotor activation, nor did it exhibit any aversive or reinforcing properties. The results suggest that separate neural systems may subserve the motor and rewarding properties of amphetamine.
KW - Conditioned place preference
KW - d-Amphetamine
KW - Dopamine
KW - GABA
KW - Locomotor activity
KW - SL 76002
UR - http://www.scopus.com/inward/record.url?scp=0021920381&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(85)90069-X
DO - 10.1016/0014-2999(85)90069-X
M3 - Article
C2 - 2984007
AN - SCOPUS:0021920381
SN - 0014-2999
VL - 107
SP - 271
EP - 274
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2
ER -