The effects of progabide (SL 76002) on locomotor activity and conditioned place preference induced by d-Amphetamine

Georges Di Scala, Mathew T. Martin-Iverson, Anthony G. Phillips, Hans C. Fibiger

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The effect of prior treatment with a GABA mimetic, SL 76002 (100 mg/kg i.p.), on amphetamine-induced locomotor activity and conditioned place preferences with amphetamine (1.5 mg/kg i.p.) was investigated. SL 76002 significantly attenuated the motor stimulant effects of amphetamine, without influencing the rewarding properties at least as determined by the place preference procedure. When injected alone, SL 76002 did not affect handling-induced locomotor activation, nor did it exhibit any aversive or reinforcing properties. The results suggest that separate neural systems may subserve the motor and rewarding properties of amphetamine.

Original languageEnglish
Pages (from-to)271-274
Number of pages4
JournalEuropean Journal of Pharmacology
Volume107
Issue number2
DOIs
Publication statusPublished - 2 Jan 1985
Externally publishedYes

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