TY - JOUR
T1 - The effects of oral trehalose on glycaemia, inflammation, and quality of life in patients with type 2 diabetes
T2 - a pilot randomized controlled trial
AU - Hashemian, Somayyeh
AU - Shojaei, Mehrnaz
AU - Radbakhsh, Shabnam
AU - Ashari, Sorour
AU - Riahi, Maryam Matbou
AU - Amiri, Zeinab Shateri
AU - Atkin, Stephen L.
AU - Banach, Maciej
AU - Bagherniya, Mohammad
AU - Emami, Seyed Ahmad
AU - Sahebkar, Amirhossein
N1 - Funding Information:
Trial registration: IRCT20130829014521N18. We are thankful for the financial support from the National Institute for Medical Research Development (NIMAD), Tehran, Iran (Grant No. 996398).
Publisher Copyright:
Copyright © 2023 Termedia & Banach.
PY - 2023/11/13
Y1 - 2023/11/13
N2 - Introduction: Trehalose is a naturally occurring disaccharide of 2 glucose molecules, which has been suggested as a potential therapeutic agent to reduce blood glucose and ameliorate diabetes-related complications in type 2 diabetes (T2D). This study aimed to determine the efficacy of medium-term trehalose treatment in patients with T2D. Material and methods: A double-blind, randomized, placebo-controlled trial in 40 patients with T2D was undertaken; 20 ingested trehalose 3.3 g/day and 20 placebo (sucrose), for 3 months. Parameters of glycaemic indices, high-sensitivity C-reactive protein (CRP), mood status, and quality of life were measured. Results: CRP was significantly lower with trehalose treatment (–0.62 ±0.3 mg/l, p = 0.02); however, no differences in glycaemic indices of fasting blood glucose (FBG) (–7.1 ±10.7 mg/dl, p = 0.15), glycated hemoglobin (HbA1c) (–0.1 ±0.4%, p = 0.73), insulin (0.73 ±0.8 µU/ml, p = 0.39), or insulin resistance (HOMA-IR) (0.19 ±0.33, p = 0.56) were seen between groups after 12 weeks. Depression and stress scores were lower with trehalose compared to the placebo group (p = 0.02 and p = 0.05, respectively), whilst the quality-of-life score was higher with trehalose compared to placebo (p = 0.03) at the end of study. Between-group differences in these indices did not reach statistical significance (–2.36 ±1.20, –2.21 ±1.39 and 3.00 ±1.76 for depression, stress, and quality-of-life score, respectively) (p > 0.05). The pro-oxidant antioxidant balance (PAB) did not differ between groups (–4.6 ±12.8, p = 0.72). Conclusions: 12 weeks of treatment with 3.3 g/day of oral trehalose significantly improves CRP as a marker of inflammation, with potential favourable effects on quality of life, depression, and stress levels, but overall glycaemic control and pro-oxidant-antioxidant balance were unaltered during this time frame.
AB - Introduction: Trehalose is a naturally occurring disaccharide of 2 glucose molecules, which has been suggested as a potential therapeutic agent to reduce blood glucose and ameliorate diabetes-related complications in type 2 diabetes (T2D). This study aimed to determine the efficacy of medium-term trehalose treatment in patients with T2D. Material and methods: A double-blind, randomized, placebo-controlled trial in 40 patients with T2D was undertaken; 20 ingested trehalose 3.3 g/day and 20 placebo (sucrose), for 3 months. Parameters of glycaemic indices, high-sensitivity C-reactive protein (CRP), mood status, and quality of life were measured. Results: CRP was significantly lower with trehalose treatment (–0.62 ±0.3 mg/l, p = 0.02); however, no differences in glycaemic indices of fasting blood glucose (FBG) (–7.1 ±10.7 mg/dl, p = 0.15), glycated hemoglobin (HbA1c) (–0.1 ±0.4%, p = 0.73), insulin (0.73 ±0.8 µU/ml, p = 0.39), or insulin resistance (HOMA-IR) (0.19 ±0.33, p = 0.56) were seen between groups after 12 weeks. Depression and stress scores were lower with trehalose compared to the placebo group (p = 0.02 and p = 0.05, respectively), whilst the quality-of-life score was higher with trehalose compared to placebo (p = 0.03) at the end of study. Between-group differences in these indices did not reach statistical significance (–2.36 ±1.20, –2.21 ±1.39 and 3.00 ±1.76 for depression, stress, and quality-of-life score, respectively) (p > 0.05). The pro-oxidant antioxidant balance (PAB) did not differ between groups (–4.6 ±12.8, p = 0.72). Conclusions: 12 weeks of treatment with 3.3 g/day of oral trehalose significantly improves CRP as a marker of inflammation, with potential favourable effects on quality of life, depression, and stress levels, but overall glycaemic control and pro-oxidant-antioxidant balance were unaltered during this time frame.
KW - antioxidant
KW - diabetes
KW - glycaemic indies
KW - quality of life
KW - randomized controlled trial
KW - trehalose
UR - http://www.scopus.com/inward/record.url?scp=85176779743&partnerID=8YFLogxK
U2 - 10.5114/aoms/159048
DO - 10.5114/aoms/159048
M3 - Article
C2 - 38058700
AN - SCOPUS:85176779743
SN - 1734-1922
VL - 19
SP - 1693
EP - 1700
JO - Archives of Medical Science
JF - Archives of Medical Science
IS - 6
ER -