The Effects of Inhalation of a Novel Nitric Oxide Donor, DETA/NO, in a Patient with Severe Hypoxaemia Due to Acute Respiratory Distress Syndrome

C-F. Lam, Peter Van Heerden, S. Sviri, B.L. Roberts, Kenneth Ilett

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Aerosolized NONOates have been investigated in animal models in acute pulmonary hypertension, but none have been used in humans. We report the first use of aerosolized diethylenetrianzine nitric oxide adduct (DETA/NO), a NONOate, in a patient with severe acute respiratory distress syndrome. Both pulmonary vascular resistance index and mean pulmonary arterial pressure were reduced by a mean of 26% and 18% respectively after the administration of a single dose of DETA/NO (150 mumol). Intrapulmonary shunting also improved. There were no significant changes in systemic arterial pressure or arterial methaemoglobin concentration after DETA/NO inhalation. We conclude that DETA/NO aerosol produced selective pulmonary vasodilation, with an improvement in pulmonary haemodynamics and oxygenation, while having no measurable effect on the systemic circulation.
Original languageEnglish
Pages (from-to)472-476
JournalAnaesthesia and Intensive Care
Volume30
Publication statusPublished - 2002

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