The Effects of Hypochlorous Acid on Skeletal Muscle Function: Implications for the Pathophysiology of Duchenne Muscular Dystrophy

Research output: ThesisDoctoral Thesis

208 Downloads (Pure)

Abstract

This thesis investigated the effects of hypochlorous acid (HOCl) on skeletal muscle function and implications for the pathophysiology of Duchenne Muscular Dystrophy (DMD). The mechanisms of muscle wasting in DMD remain unclear which is a significant barrier to developing treatments. The results from this thesis indicate that HOCl impairs muscle function via its effects on Ca2+ handling and contractile proteins and therefore may contribute to the pathophysiology of DMD. Increased levels of HOCl in dystrophic muscle may explain the link between inflammation, oxidative stress and impaired Ca2+ handling and represents an important target for the development of new DMD therapies.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Pinniger, Gavin, Supervisor
  • Arthur, Peter, Supervisor
  • Bakker, Tony, Supervisor
Thesis sponsors
Award date19 Jan 2023
DOIs
Publication statusUnpublished - 2023

Fingerprint

Dive into the research topics of 'The Effects of Hypochlorous Acid on Skeletal Muscle Function: Implications for the Pathophysiology of Duchenne Muscular Dystrophy'. Together they form a unique fingerprint.

Cite this