TY - CHAP
T1 - The Effects of Ginsenosides on the Nrf2 Signaling Pathway
AU - Ashrafizadeh, Milad
AU - Ahmadi, Zahra
AU - Yaribeygi, Habib
AU - Sathyapalan, Thozhukat
AU - Jamialahmadi, Tannaz
AU - Sahebkar, Amirhossein
PY - 2021
Y1 - 2021
N2 - Nuclear factor erythroid-2 related factor 2 (Nrf2) is a major signaling pathway for the maintenance of homeostasis and redox balance. This pathway also plays a significant role in proteostasis, xenobiotic/drug metabolism, apoptosis, and lipid and carbohydrate metabolism. Conversely, the Nrf2 signaling pathway is impaired in several pathological conditions including cancer. Although various drugs have been developed to target the Nrf2 pathway, plant-derived chemicals than can potentially impact this pathway and are particularly attractive due to their minimal side effects. Ginsenosides are active components of ginseng and have been shown to exert pharmacological effects including antioxidant, anti-inflammatory, antitumor, antidiabetes, neuroprotective, and hepatoprotective activities. In this article, we have reviewed the effects of ginsenosides on Nrf2 signaling pathway.
AB - Nuclear factor erythroid-2 related factor 2 (Nrf2) is a major signaling pathway for the maintenance of homeostasis and redox balance. This pathway also plays a significant role in proteostasis, xenobiotic/drug metabolism, apoptosis, and lipid and carbohydrate metabolism. Conversely, the Nrf2 signaling pathway is impaired in several pathological conditions including cancer. Although various drugs have been developed to target the Nrf2 pathway, plant-derived chemicals than can potentially impact this pathway and are particularly attractive due to their minimal side effects. Ginsenosides are active components of ginseng and have been shown to exert pharmacological effects including antioxidant, anti-inflammatory, antitumor, antidiabetes, neuroprotective, and hepatoprotective activities. In this article, we have reviewed the effects of ginsenosides on Nrf2 signaling pathway.
KW - Ginseng
KW - Ginsenosides
KW - Herbal medicine
KW - Nrf2 signaling pathway
KW - Protective effects
UR - http://www.scopus.com/inward/record.url?scp=85122503816&partnerID=8YFLogxK
U2 - 10.1007/978-3-030-73234-9_20
DO - 10.1007/978-3-030-73234-9_20
M3 - Chapter
C2 - 34981486
AN - SCOPUS:85122503816
SN - 978-3-030-73233-2
T3 - Advances in Experimental Medicine and Biology
SP - 307
EP - 322
BT - Natural Products and Human Diseases
A2 - Sahebkar, Amirhossein
A2 - Sathyapalan, Thozhukat
PB - Springer Heidelberg
CY - Switzerland
ER -
