The Effects of Ginsenosides on the Nrf2 Signaling Pathway

Milad Ashrafizadeh, Zahra Ahmadi, Habib Yaribeygi, Thozhukat Sathyapalan, Tannaz Jamialahmadi, Amirhossein Sahebkar

Research output: Chapter in Book/Conference paperChapterpeer-review

2 Citations (Scopus)


Nuclear factor erythroid-2 related factor 2 (Nrf2) is a major signaling pathway for the maintenance of homeostasis and redox balance. This pathway also plays a significant role in proteostasis, xenobiotic/drug metabolism, apoptosis, and lipid and carbohydrate metabolism. Conversely, the Nrf2 signaling pathway is impaired in several pathological conditions including cancer. Although various drugs have been developed to target the Nrf2 pathway, plant-derived chemicals than can potentially impact this pathway and are particularly attractive due to their minimal side effects. Ginsenosides are active components of ginseng and have been shown to exert pharmacological effects including antioxidant, anti-inflammatory, antitumor, antidiabetes, neuroprotective, and hepatoprotective activities. In this article, we have reviewed the effects of ginsenosides on Nrf2 signaling pathway.

Original languageEnglish
Title of host publicationNatural Products and Human Diseases
Subtitle of host publicationPharmacology, Molecular Targets, and Therapeutic Benefits
EditorsAmirhossein Sahebkar, Thozhukat Sathyapalan
Place of PublicationSwitzerland
PublisherSpringer Heidelberg
Number of pages16
ISBN (Electronic)978-3-030-73234-9
ISBN (Print)978-3-030-73233-2
Publication statusPublished - 2021

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


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