Abstract
[Truncated] Cytotoxic chemotherapy is an important and commonly used modality of cancer treatment. Although most cytotoxic drugs cause neutropenia and lymphopenia, and are considered immunosuppressive, there are few data on the effects of chemotherapy on the humoral and cellular immune responses to specific tumour antigens. In order to bring together chemotherapy and immunotherapies, it is important to understand the effects chemotherapy on the immune response, and how to rationally combine these treatments.
My first aim was to study the effects of the cytotoxic drug gemcitabine on the humoral and cellular response to a specific tumour antigen in a solid tumour model. I used a tumour model system in which a murine mesothelioma cell line has been transfected with the influenza haemagglutinin antigen (AB1-HA). A gemcitabine-resistant line of AB1-HA was also generated. Changes in the immune response to HA were followed using various tools including anti-HATCR transgenic lymphocytes.
My first aim was to study the effects of the cytotoxic drug gemcitabine on the humoral and cellular response to a specific tumour antigen in a solid tumour model. I used a tumour model system in which a murine mesothelioma cell line has been transfected with the influenza haemagglutinin antigen (AB1-HA). A gemcitabine-resistant line of AB1-HA was also generated. Changes in the immune response to HA were followed using various tools including anti-HATCR transgenic lymphocytes.
| Original language | English |
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| Qualification | Doctor of Philosophy |
| Awarding Institution |
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| DOIs | |
| Publication status | Unpublished - 2002 |
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- Nowak_Katherine_Anna_2002
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