Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 577-581 |
| Number of pages | 5 |
| Journal | Journal of Comparative Physiology B |
| Volume | 155 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1985 |
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The effects of erythrocythemia on blood viscosity, maximal systemic oxygen transport capacity and maximal rates of oxygen consumption in an amphibian. / Hillman, S.S.; Withers, P.C.; Hedrick, M.S.; Kimmel, P.B.
In: Journal of Comparative Physiology B, Vol. 155, No. 5, 1985, p. 577-581.Research output: Contribution to journal › Article
TY - JOUR
T1 - The effects of erythrocythemia on blood viscosity, maximal systemic oxygen transport capacity and maximal rates of oxygen consumption in an amphibian
AU - Hillman, S.S.
AU - Withers, P.C.
AU - Hedrick, M.S.
AU - Kimmel, P.B.
PY - 1985
Y1 - 1985
N2 - 1. Graded erythrocythemia was induced by isovolemic loading of packed red blood cells in the toad, Bufo marinus. Blood viscosity, hematocrit, hemoglobin concentration, maximal aortic blood flow rate and maximal rates of oxygen consumption were determined after each load. 2. Blood viscosity was related to hematocrit in the expected exponential manner; ln η=0.43+0.035 Hct (Fig. 2). 3. Maximal blood flow rates in the dorsal aorta were inversely proportional to blood viscosity and fit predictions of the Poiseuille-Hagen flow formula (Fig. 3). The effect of increased blood viscosity was to reduce aortic pulse volume, but not maximal heart rate (Figs. 4, 5). 4. Maximal systemic oxygen transport capacity (aortic blood flow rate x hemoglobin concentration x O2 binding capacity of hemoglobin) was linearly correlated with the maximal rate of oxygen consumption (Fig. 6). 5. These data indicate that optimal hematocrit theory is applicable for maximal blood flow rates in vivo, and that systemic oxygen transport is the primary limitation to aerial {Mathematical expression} max in amphibians. © 1985 Springer-Verlag.
AB - 1. Graded erythrocythemia was induced by isovolemic loading of packed red blood cells in the toad, Bufo marinus. Blood viscosity, hematocrit, hemoglobin concentration, maximal aortic blood flow rate and maximal rates of oxygen consumption were determined after each load. 2. Blood viscosity was related to hematocrit in the expected exponential manner; ln η=0.43+0.035 Hct (Fig. 2). 3. Maximal blood flow rates in the dorsal aorta were inversely proportional to blood viscosity and fit predictions of the Poiseuille-Hagen flow formula (Fig. 3). The effect of increased blood viscosity was to reduce aortic pulse volume, but not maximal heart rate (Figs. 4, 5). 4. Maximal systemic oxygen transport capacity (aortic blood flow rate x hemoglobin concentration x O2 binding capacity of hemoglobin) was linearly correlated with the maximal rate of oxygen consumption (Fig. 6). 5. These data indicate that optimal hematocrit theory is applicable for maximal blood flow rates in vivo, and that systemic oxygen transport is the primary limitation to aerial {Mathematical expression} max in amphibians. © 1985 Springer-Verlag.
U2 - 10.1007/BF00694447
DO - 10.1007/BF00694447
M3 - Article
VL - 155
SP - 577
EP - 581
JO - Journal of Comparative Physiology B: biochemical, systemic, and environmental physiology
JF - Journal of Comparative Physiology B: biochemical, systemic, and environmental physiology
SN - 0174-1578
IS - 5
ER -