The effects of erythrocythemia on blood viscosity, maximal systemic oxygen transport capacity and maximal rates of oxygen consumption in an amphibian

S.S. Hillman, P.C. Withers, M.S. Hedrick, P.B. Kimmel

Research output: Contribution to journalArticle

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Abstract

1. Graded erythrocythemia was induced by isovolemic loading of packed red blood cells in the toad, Bufo marinus. Blood viscosity, hematocrit, hemoglobin concentration, maximal aortic blood flow rate and maximal rates of oxygen consumption were determined after each load. 2. Blood viscosity was related to hematocrit in the expected exponential manner; ln η=0.43+0.035 Hct (Fig. 2). 3. Maximal blood flow rates in the dorsal aorta were inversely proportional to blood viscosity and fit predictions of the Poiseuille-Hagen flow formula (Fig. 3). The effect of increased blood viscosity was to reduce aortic pulse volume, but not maximal heart rate (Figs. 4, 5). 4. Maximal systemic oxygen transport capacity (aortic blood flow rate x hemoglobin concentration x O2 binding capacity of hemoglobin) was linearly correlated with the maximal rate of oxygen consumption (Fig. 6). 5. These data indicate that optimal hematocrit theory is applicable for maximal blood flow rates in vivo, and that systemic oxygen transport is the primary limitation to aerial {Mathematical expression} max in amphibians. © 1985 Springer-Verlag.
Original languageEnglish
Pages (from-to)577-581
Number of pages5
JournalJournal of Comparative Physiology B
Volume155
Issue number5
DOIs
Publication statusPublished - 1985

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blood viscosity
Blood Viscosity
Amphibians
oxygen consumption
Oxygen Consumption
amphibian
blood flow
amphibians
Blood
viscosity
blood
Hematocrit
Viscosity
Oxygen
hematocrit
oxygen
hemoglobin
Hemoglobins
Bufo marinus
Flow rate

Cite this

@article{e079fe5a9f4744258c461d01063099c7,
title = "The effects of erythrocythemia on blood viscosity, maximal systemic oxygen transport capacity and maximal rates of oxygen consumption in an amphibian",
abstract = "1. Graded erythrocythemia was induced by isovolemic loading of packed red blood cells in the toad, Bufo marinus. Blood viscosity, hematocrit, hemoglobin concentration, maximal aortic blood flow rate and maximal rates of oxygen consumption were determined after each load. 2. Blood viscosity was related to hematocrit in the expected exponential manner; ln η=0.43+0.035 Hct (Fig. 2). 3. Maximal blood flow rates in the dorsal aorta were inversely proportional to blood viscosity and fit predictions of the Poiseuille-Hagen flow formula (Fig. 3). The effect of increased blood viscosity was to reduce aortic pulse volume, but not maximal heart rate (Figs. 4, 5). 4. Maximal systemic oxygen transport capacity (aortic blood flow rate x hemoglobin concentration x O2 binding capacity of hemoglobin) was linearly correlated with the maximal rate of oxygen consumption (Fig. 6). 5. These data indicate that optimal hematocrit theory is applicable for maximal blood flow rates in vivo, and that systemic oxygen transport is the primary limitation to aerial {Mathematical expression} max in amphibians. {\circledC} 1985 Springer-Verlag.",
author = "S.S. Hillman and P.C. Withers and M.S. Hedrick and P.B. Kimmel",
year = "1985",
doi = "10.1007/BF00694447",
language = "English",
volume = "155",
pages = "577--581",
journal = "Journal of Comparative Physiology B: biochemical, systemic, and environmental physiology",
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The effects of erythrocythemia on blood viscosity, maximal systemic oxygen transport capacity and maximal rates of oxygen consumption in an amphibian. / Hillman, S.S.; Withers, P.C.; Hedrick, M.S.; Kimmel, P.B.

In: Journal of Comparative Physiology B, Vol. 155, No. 5, 1985, p. 577-581.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The effects of erythrocythemia on blood viscosity, maximal systemic oxygen transport capacity and maximal rates of oxygen consumption in an amphibian

AU - Hillman, S.S.

AU - Withers, P.C.

AU - Hedrick, M.S.

AU - Kimmel, P.B.

PY - 1985

Y1 - 1985

N2 - 1. Graded erythrocythemia was induced by isovolemic loading of packed red blood cells in the toad, Bufo marinus. Blood viscosity, hematocrit, hemoglobin concentration, maximal aortic blood flow rate and maximal rates of oxygen consumption were determined after each load. 2. Blood viscosity was related to hematocrit in the expected exponential manner; ln η=0.43+0.035 Hct (Fig. 2). 3. Maximal blood flow rates in the dorsal aorta were inversely proportional to blood viscosity and fit predictions of the Poiseuille-Hagen flow formula (Fig. 3). The effect of increased blood viscosity was to reduce aortic pulse volume, but not maximal heart rate (Figs. 4, 5). 4. Maximal systemic oxygen transport capacity (aortic blood flow rate x hemoglobin concentration x O2 binding capacity of hemoglobin) was linearly correlated with the maximal rate of oxygen consumption (Fig. 6). 5. These data indicate that optimal hematocrit theory is applicable for maximal blood flow rates in vivo, and that systemic oxygen transport is the primary limitation to aerial {Mathematical expression} max in amphibians. © 1985 Springer-Verlag.

AB - 1. Graded erythrocythemia was induced by isovolemic loading of packed red blood cells in the toad, Bufo marinus. Blood viscosity, hematocrit, hemoglobin concentration, maximal aortic blood flow rate and maximal rates of oxygen consumption were determined after each load. 2. Blood viscosity was related to hematocrit in the expected exponential manner; ln η=0.43+0.035 Hct (Fig. 2). 3. Maximal blood flow rates in the dorsal aorta were inversely proportional to blood viscosity and fit predictions of the Poiseuille-Hagen flow formula (Fig. 3). The effect of increased blood viscosity was to reduce aortic pulse volume, but not maximal heart rate (Figs. 4, 5). 4. Maximal systemic oxygen transport capacity (aortic blood flow rate x hemoglobin concentration x O2 binding capacity of hemoglobin) was linearly correlated with the maximal rate of oxygen consumption (Fig. 6). 5. These data indicate that optimal hematocrit theory is applicable for maximal blood flow rates in vivo, and that systemic oxygen transport is the primary limitation to aerial {Mathematical expression} max in amphibians. © 1985 Springer-Verlag.

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DO - 10.1007/BF00694447

M3 - Article

VL - 155

SP - 577

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JO - Journal of Comparative Physiology B: biochemical, systemic, and environmental physiology

JF - Journal of Comparative Physiology B: biochemical, systemic, and environmental physiology

SN - 0174-1578

IS - 5

ER -